近平滑念珠菌线粒体呼吸途径的抑制增强了对卡泊芬净的敏感性。
Inhibition of Candida parapsilosis mitochondrial respiratory pathways enhances susceptibility to caspofungin.
作者信息
Chamilos Georgios, Lewis Russell E, Kontoyiannis Dimitrios P
机构信息
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
出版信息
Antimicrob Agents Chemother. 2006 Feb;50(2):744-7. doi: 10.1128/AAC.50.2.744-747.2006.
Abstract
Among the Candida species, Candida parapsilosis has a unique mitochondrial respiratory network. The addition of inhibitors of the respiratory pathways in three clinical isolates of C. parapsilosis with high (> or =2- microg/ml) MICs of caspofungin significantly (fivefold) decreased caspofungin MICs but did not change fluconazole MICs.
摘要
在念珠菌属中，近平滑念珠菌具有独特的线粒体呼吸网络。在三株对卡泊芬净的最低抑菌浓度（MIC）较高（≥2微克/毫升）的近平滑念珠菌临床分离株中添加呼吸途径抑制剂，可显著（五倍）降低卡泊芬净的MIC，但不改变氟康唑的MIC。
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