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Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis.

作者信息

Hales C N, Barker D J

机构信息

Department of Clinical Biochemistry, Addenbrooke's Hospital, Cambridge, UK.

出版信息

Diabetologia. 1992 Jul;35(7):595-601. doi: 10.1007/BF00400248.

DOI:10.1007/BF00400248
PMID:1644236
Abstract
摘要

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Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis.2型（非胰岛素依赖型）糖尿病：节俭表型假说。
Diabetologia. 1992 Jul;35(7):595-601. doi: 10.1007/BF00400248.
2
Fetal and infant influences on non-insulin-dependent diabetes mellitus (NIDDM).
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3
--to: Hales CN, Barker DJP (1992) Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 35:595-601.致：黑尔斯·C·N、巴克·D·J·P（1992年）《2型（非胰岛素依赖型）糖尿病：节俭表型假说》。《糖尿病学》35卷：595 - 601页。
Diabetologia. 2003 Feb;46(2):303-4. doi: 10.1007/s00125-002-1024-1. Epub 2003 Feb 12.
4
Hypothesis: muscle insulin resistance is the ("not-so") thrifty genotype.
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Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. 1992.2型（非胰岛素依赖型）糖尿病：节俭表型假说。1992年。
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The thrifty phenotype hypothesis.节俭表型假说。
Br Med Bull. 2001;60:5-20. doi: 10.1093/bmb/60.1.5.
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Thrifty yes, genetic no.节俭是，基因否。
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The thrifty 'catch-up fat' phenotype: its impact on insulin sensitivity during growth trajectories to obesity and metabolic syndrome.节俭型“追赶性脂肪”表型：其对肥胖和代谢综合征生长轨迹中胰岛素敏感性的影响。
Int J Obes (Lond). 2006 Dec;30 Suppl 4:S23-35. doi: 10.1038/sj.ijo.0803516.
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The 'thrifty' hypotheses: clinical and epidemiological significance for non-insulin-dependent diabetes mellitus and cardiovascular disease risk factors.“节俭”假说：对非胰岛素依赖型糖尿病和心血管疾病危险因素的临床及流行病学意义
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Type 2 diabetes, the thrifty phenotype - an overview.2型糖尿病，节俭表型——综述
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The biosynthesis of insulin and a probable precursor of insulin by a human islet cell adenoma.人胰岛细胞腺瘤中胰岛素及胰岛素可能前体的生物合成。
Proc Natl Acad Sci U S A. 1967 Feb;57(2):473-80. doi: 10.1073/pnas.57.2.473.
2
Excessive insulin response to glucose in obese subjects as measured by immunochemical assay.通过免疫化学测定法测得，肥胖受试者对葡萄糖的胰岛素反应过度。
Diabetes. 1963 May-Jun;12:197-204. doi: 10.2337/diab.12.3.197.
3
Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"?糖尿病：一种因“进步”而变得有害的“节俭”基因型？
出生时体型较小可能与成年女性的身体活动量较低有关。
Sci Rep. 2025 Aug 20;15(1):30652. doi: 10.1038/s41598-025-14620-w.
4
Under-nutrition and its associated factors among under-five children across urban and rural settings of Ethiopia: a cross-sectional comparative study.埃塞俄比亚城乡地区五岁以下儿童的营养不良及其相关因素：一项横断面比较研究。
BMC Nutr. 2025 Jul 29;11(1):151. doi: 10.1186/s40795-025-01137-8.
5
Metformin use in gestational diabetes is not associated with an increased risk of preterm labor and small for gestational age infants compared to diet control alone.与单纯饮食控制相比，妊娠期糖尿病患者使用二甲双胍不会增加早产和小于胎龄儿的风险。
BMC Pregnancy Childbirth. 2025 Jul 14;25(1):762. doi: 10.1186/s12884-025-07869-6.
6
Epiphenomena in psychosis: how perinatal stressful events shape long-term outcomes.精神病中的副现象：围产期应激事件如何塑造长期结局。
Mol Psychiatry. 2025 Jul 11. doi: 10.1038/s41380-025-03096-9.
7
Early-life undernutrition increases the risk of death from chronic diseases in adulthood: a population-based cohort study.生命早期营养不良会增加成年后患慢性病死亡的风险：一项基于人群的队列研究。
Glob Health Res Policy. 2025 Jul 10;10(1):28. doi: 10.1186/s41256-025-00422-0.
8
The impact of short maternal height on gestational diabetes.母亲身高过矮对妊娠期糖尿病的影响。
Acta Diabetol. 2025 Jul 5. doi: 10.1007/s00592-025-02530-2.
9
Evaluation of pregnancy outcomes in patients with a history of bariatric surgery.对有减肥手术史患者的妊娠结局评估。
Front Med (Lausanne). 2025 Jun 11;12:1609344. doi: 10.3389/fmed.2025.1609344. eCollection 2025.
10
Effect of Recombinant Human Growth Hormone (rhGH) Use on Genetic Methylation Patterns and Their Relationship with Body Composition in Small-for-Gestational-Age (SGA) Newborns.重组人生长激素（rhGH）的使用对小于胎龄（SGA）新生儿基因甲基化模式的影响及其与身体组成的关系。
Biomedicines. 2025 May 23;13(6):1288. doi: 10.3390/biomedicines13061288.
Am J Hum Genet. 1962 Dec;14(4):353-62.
4
Incidence of diabetes amongst people aged 18-50 years in nine British towns: a collaborative study.英国九个城镇18至50岁人群的糖尿病发病率：一项合作研究。
Diabetologia. 1982 Jun;22(6):421-5. doi: 10.1007/BF00282583.
5
Evidence for an autosomal recessive gene regulating the persistence of the insulin response to glucose in man.关于一个常染色体隐性基因调控人体对葡萄糖胰岛素反应持续性的证据。
Clin Genet. 1982 Oct;22(4):180-94. doi: 10.1111/j.1399-0004.1982.tb01432.x.
6
Proinsulin in human serum: problems in measurement and interpretation.人血清中的胰岛素原：测量与解读方面的问题
Clin Endocrinol (Oxf). 1984 Jul;21(1):43-7. doi: 10.1111/j.1365-2265.1984.tb00134.x.
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Cell populations in the endocrine pancreas of human neonates and infants.人类新生儿和婴儿内分泌胰腺中的细胞群体。
Diabetologia. 1981 May;20(5):540-6. doi: 10.1007/BF00252762.
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Coronary-heart-disease risk and impaired glucose tolerance. The Whitehall study.冠心病风险与糖耐量受损。白厅研究。
Lancet. 1980 Jun 28;1(8183):1373-6. doi: 10.1016/s0140-6736(80)92651-3.
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Plasma insulin responses to oral and intravenous glucose: studies in normal and diabetic sujbjects.血浆胰岛素对口服及静脉注射葡萄糖的反应：对正常及糖尿病受试者的研究。
J Clin Invest. 1967 Dec;46(12):1954-62. doi: 10.1172/JCI105685.
10
Cellular response in rats during malnutrition at various ages.不同年龄段大鼠在营养不良期间的细胞反应。
J Nutr. 1966 Jul;89(3):300-6. doi: 10.1093/jn/89.3.300.