Department of Pediatrics, Division of Neonatology, University of Oklahoma Health Sciences Center, 1200 North Everett Drive, ETNP7504, Oklahoma City, OK 73104, USA.
Int J Mol Sci. 2019 Apr 18;20(8):1912. doi: 10.3390/ijms20081912.
Intestinal inflammatory diseases, such as Crohn's disease, ulcerative colitis, and necrotizing enterocolitis, are becoming increasingly prevalent. While knowledge of the pathogenesis of these related diseases is currently incomplete, each of these conditions is thought to involve a dysfunctional, or overstated, host immunological response to both bacteria and dietary antigens, resulting in unchecked intestinal inflammation and, often, alterations in the intestinal microbiome. This inflammation can result in an impaired intestinal barrier allowing for bacterial translocation, potentially resulting in systemic inflammation and, in severe cases, sepsis. Chronic inflammation of this nature, in the case of inflammatory bowel disease, can even spur cancer growth in the longer-term. Recent research has indicated certain natural products with anti-inflammatory properties, such as curcumin, can help tame the inflammation involved in intestinal inflammatory diseases, thus improving intestinal barrier function, and potentially, clinical outcomes. In this review, we explore the potential therapeutic properties of curcumin on intestinal inflammatory diseases, including its antimicrobial and immunomodulatory properties, as well as its potential to alter the intestinal microbiome. Curcumin may play a significant role in intestinal inflammatory disease treatment in the future, particularly as an adjuvant therapy.
肠道炎症性疾病（如克罗恩病、溃疡性结肠炎和坏死性小肠结肠炎）的发病率正在不断上升。尽管目前对这些相关疾病的发病机制还不完全了解，但人们认为每种疾病都涉及宿主免疫功能失调或过度活跃，对细菌和饮食抗原均产生反应，导致肠道炎症失控，通常还会导致肠道微生物组发生改变。这种炎症会导致肠道屏障受损，允许细菌易位，可能导致全身炎症，在严重的情况下，还会导致败血症。在炎症性肠病的情况下，这种性质的慢性炎症甚至会刺激癌症的长期生长。最近的研究表明，某些具有抗炎特性的天然产物，如姜黄素，可以帮助控制肠道炎症性疾病所涉及的炎症，从而改善肠道屏障功能，并可能改善临床结果。在本文中，我们探讨了姜黄素对肠道炎症性疾病的潜在治疗特性，包括其抗菌和免疫调节特性，以及改变肠道微生物组的潜力。姜黄素在未来的肠道炎症性疾病治疗中可能发挥重要作用，特别是作为辅助治疗。
