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1
Retinopathy and microalbuminuria in type II diabetic patients.II型糖尿病患者的视网膜病变和微量白蛋白尿
BMC Ophthalmol. 2004 Jul 1;4:9. doi: 10.1186/1471-2415-4-9.
2
Vascular dysfunction and autonomic neuropathy in Type 2 diabetes.2型糖尿病中的血管功能障碍与自主神经病变
Diabet Med. 2004 Jul;21(7):746-51. doi: 10.1111/j.1464-5491.2004.01241.x.
3
Interleukin-6 promoter genotype and restenosis after femoropopliteal balloon angioplasty: initial observations.
Radiology. 2004 Jun;231(3):839-44. doi: 10.1148/radiol.2312030707. Epub 2004 Apr 22.
4
The -174G/C polymorphism of IL-6 is useful to screen old subjects at risk for atherosclerosis or to reach successful ageing.白细胞介素-6的-174G/C多态性有助于筛查有动脉粥样硬化风险的老年受试者或实现成功衰老。
Exp Gerontol. 2004 Apr;39(4):621-8. doi: 10.1016/j.exger.2003.12.013.
5
C-reactive protein and risk factors for peripheral vascular disease in subjects with Type 2 diabetes mellitus.2型糖尿病患者的C反应蛋白与外周血管疾病的危险因素
Diabet Med. 2004 Apr;21(4):336-41. doi: 10.1111/j.1464-5491.2004.01144.x.
6
Effect of type 2 diabetes and its duration on the risk of peripheral arterial disease among men.
Am J Med. 2004 Feb 15;116(4):236-40. doi: 10.1016/j.amjmed.2003.09.038.
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Recent advances in vascular inflammation: C-reactive protein and other inflammatory biomarkers.血管炎症的最新进展：C反应蛋白及其他炎症生物标志物
Curr Opin Rheumatol. 2004 Jan;16(1):18-24. doi: 10.1097/00002281-200401000-00005.
8
The (-174) G/C polymorphism in the interleukin-6 gene is associated with the severity of acute cerebrovascular events.白细胞介素-6基因中（-174）G/C多态性与急性脑血管事件的严重程度相关。
Thromb Res. 2003 Jun 1;110(4):181-6. doi: 10.1016/s0049-3848(03)00376-1.
9
Association of an allelic variant of interleukin-6 with subclinical carotid atherosclerosis in an Australian community population.白细胞介素-6等位基因变体与澳大利亚社区人群亚临床颈动脉粥样硬化的关联。
Eur Heart J. 2003 Aug;24(16):1494-9. doi: 10.1016/s0195-668x(03)00313-0.
10
Endothelial dysfunction in peripheral arterial disease is related to increase in plasma markers of inflammation and severity of peripheral circulatory impairment but not to classic risk factors and atherosclerotic burden.外周动脉疾病中的内皮功能障碍与炎症血浆标志物增加及外周循环障碍的严重程度相关，而与经典危险因素和动脉粥样硬化负担无关。
J Vasc Surg. 2003 Aug;38(2):374-9. doi: 10.1016/s0741-5214(03)00124-1.

2型糖尿病合并外周动脉疾病患者G(-174)C白细胞介素-6基因多态性及炎症标志物血浆浓度分析

Analysis of G(-174)C IL-6 polymorphism and plasma concentrations of inflammatory markers in patients with type 2 diabetes and peripheral arterial disease.

作者信息

Libra M, Signorelli S S, Bevelacqua Y, Navolanic P M, Bevelacqua V, Polesel J, Talamini R, Stivala F, Mazzarino M C, Malaponte G

机构信息

Department of Biomedical Sciences, University of Catania, Via Androne, 83-95124, Catania, Italy.

出版信息

J Clin Pathol. 2006 Feb;59(2):211-5. doi: 10.1136/jcp.2004.025452.

DOI:10.1136/jcp.2004.025452
PMID:16443741
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1860309/
Abstract

AIMS

To determine whether the G(-174)C interleukin 6 (IL-6) polymorphism influences the development of peripheral arterial disease (PAD) in individuals with type 2 diabetes. This was investigated by comparing the distribution of G(-174)C genotypes between patients with type 2 diabetes and PAD (PAD+) and those with type 2 diabetes but without PAD (PAD-). Plasma concentrations of IL-6, fibrinogen, C reactive protein (CRP), and vascular endothelial growth factor (VEGF) were also compared in PAD+ and PAD- patients.

METHODS

Blood samples were collected from 146 PAD+ and 144 PAD- patients. SfaNI was used to determine the G(-174)C genotype. Plasma concentrations of IL-6, fibrinogen, CRP, and VEGF were measured by an enzyme linked immunosorbent assay.

RESULTS

The GG genotype was more common in PAD+ patients than in PAD- patients. PAD+ patients also had increased mean plasma concentrations of IL-6, fibrinogen, CRP, and VEGF compared with PAD- patients. Mean plasma concentrations of IL-6, fibrinogen, and CRP in both PAD+ and PAD- patients were higher in those with the GG genotype than in those with the GC or CC genotypes. In contrast, mean plasma concentrations of VEGF in PAD+ and PAD- patients were not significantly different between those with different G(-174)C genotypes.

CONCLUSIONS

These results support a model in which the GG genotype promotes PAD development among individuals with type 2 diabetes by inducing increased release of IL-6. Higher concentrations of IL-6 among those with the GG genotype is associated with increased plasma concentrations of fibrinogen and CRP.

摘要

目的

确定白细胞介素6（IL-6）基因G（-174）C多态性是否会影响2型糖尿病患者外周动脉疾病（PAD）的发生发展。通过比较2型糖尿病合并PAD患者（PAD+）与2型糖尿病但无PAD患者（PAD-）之间G（-174）C基因型的分布情况来进行研究。同时，还比较了PAD+和PAD-患者血浆中IL-6、纤维蛋白原、C反应蛋白（CRP）和血管内皮生长因子（VEGF）的浓度。

方法

采集了146例PAD+患者和144例PAD-患者的血样。采用SfaNI酶切法确定G（-174）C基因型。通过酶联免疫吸附测定法测量血浆中IL-6、纤维蛋白原、CRP和VEGF的浓度。

结果

GG基因型在PAD+患者中比在PAD-患者中更常见。与PAD-患者相比，PAD+患者血浆中IL-6、纤维蛋白原、CRP和VEGF的平均浓度也有所升高。GG基因型的PAD+和PAD-患者血浆中IL-6、纤维蛋白原和CRP的平均浓度高于GC或CC基因型的患者。相比之下，不同G（-174）C基因型的PAD+和PAD-患者血浆中VEGF的平均浓度无显著差异。

结论

这些结果支持了一种模型，即GG基因型通过诱导IL-6释放增加，促进2型糖尿病患者发生PAD。GG基因型患者中较高的IL-6浓度与血浆中纤维蛋白原和CRP浓度升高有关。