用西洛芬净治疗实验性播散性念珠菌病。
Treatment of experimental disseminated candidiasis with cilofungin.
作者信息
Perfect J R, Hobbs M M, Wright K A, Durack D T
机构信息
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.
出版信息
Antimicrob Agents Chemother. 1989 Oct;33(10):1811-2. doi: 10.1128/AAC.33.10.1811.
Abstract
The efficacy of cilofungin treatment of experimental disseminated candidiasis in rabbits was examined. Cilofungin treatment reduced yeast counts, especially in the kidney, with activity comparable to that of amphotericin B. The peak level of cilofungin in serum was measured at 5 min after administration of a single dose, with no drug detectable after 90 min.
摘要
研究了西洛芬净治疗兔实验性播散性念珠菌病的疗效。西洛芬净治疗可降低酵母计数，尤其是在肾脏中，其活性与两性霉素B相当。单次给药后5分钟测定血清中西洛芬净的峰值水平，90分钟后未检测到药物。
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