Minocha Anil, Wigington William Chad, Johnson William D
Department of Medicine, Division of Digestive Diseases, University of Mississippi Medical Center, Jackson, Mississippi 39216-4505, USA.
Am J Gastroenterol. 2006 Feb;101(2):336-42. doi: 10.1111/j.1572-0241.2006.00391.x.
We wished to study the prevalence as well as the sociodemographic characteristics and quality of life (QoL) of African American patients with uninvestigated dyspepsia (UD) among the population at large and compare it to the Caucasians.
A total of 990 adults from nine different sites in the Jackson, Mississippi metropolitan area (670 African Americans and 320 Caucasians), completed self-administered questionnaires providing sociodemographic information, and details regarding bowel habits and associated symptoms for diagnosing the presence or absence of UD based on ROME II criteria. QoL was assessed by the SF-12 questionnaire.
Of the 990 participants 247 had UD, giving a total sample prevalence of 24.9% (African Americans = 24.3%, Caucasians = 26.2%). Adjusting for other risk factors in a reduced logistic regression model, we found female sex (OR 1.8; CI 1.2-2.6; p < 0.01), lower education (p < 0.01), and larger size of household (p = 0.01) to be important correlates of UD prevalence whereas the lower household income showed a trend toward statistical significance (p = 0.057). Using the adjusted odds ratio as an estimate of relative risk, Caucasians were 1.5 (95% CI = 11.1-2.1; p = 0.017) more likely than African Americans to have UD. In terms of an index for QoL on SF-12 (possible score = 1-44, with 44 being ideal), the adjusted mean score was significantly lower for adults with UD compared to non-UD adults (30.4 vs 35.0; p < 0.01). However, there was no difference in impairment of life in Caucasians versus African Americans (32.9 vs 32.5; p = 0.36).
UD occurs less frequently among African Americans. While UD affects QoL among both Caucasians and African Americans, the degree of impairment is similar.
我们希望研究非裔美国消化不良未确诊患者（UD）在普通人群中的患病率、社会人口学特征及生活质量（QoL），并与白种人进行比较。
来自密西西比州杰克逊市大都市区9个不同地点的990名成年人（670名非裔美国人，320名白种人）完成了自我管理问卷，问卷提供了社会人口学信息、肠道习惯细节以及根据罗马II标准诊断UD存在与否的相关症状。生活质量通过SF - 12问卷进行评估。
在990名参与者中，247人患有UD，总样本患病率为24.9%（非裔美国人 = 24.3%，白种人 = 26.2%）。在简化的逻辑回归模型中对其他风险因素进行调整后，我们发现女性（比值比1.8；可信区间1.2 - 2.6；p < 0.01）、低教育程度（p < 0.01）和家庭规模较大（p = 0.01）是UD患病率的重要相关因素，而家庭收入较低显示出统计学意义的趋势（p = 0.057）。以调整后的比值比作为相对风险的估计值，白种人患UD的可能性比非裔美国人高1.5倍（95%可信区间 = 1.1 - 2.1；p = 0.017）。就SF - 12生活质量指数而言（可能得分 = 1 - 44，44分为理想），与未患UD的成年人相比，患UD的成年人调整后的平均得分显著更低（30.4对35.0；p < 0.01）。然而，白种人和非裔美国人在生活受损方面没有差异（32.9对32.5；p = 0.36）。
非裔美国人中UD的发生率较低。虽然UD对白种人和非裔美国人的生活质量都有影响，但受损程度相似。
