Staner L, Luthringer R, Dupont C, Aubin H J, Lagrue G
FORENAP Research Institute for Neuroscience, Pharmacology and Psychiatry, 27, rue du 4eme RSM, 68250 Rouffach, France.
Sleep Med. 2006 Mar;7(2):147-54. doi: 10.1016/j.sleep.2005.09.008. Epub 2006 Feb 3.
Sleep disturbance is a common symptom of tobacco withdrawal and might contribute to early relapse vulnerability in abstinent smokers. This study was designed to compare the effects on sleep of nicotine patches applied either for 24 h (Nicopatch) or 16 h (Nicorette).
During a short smoking cessation period (48 h), this open-label, randomised, two-period crossover study compared the effects on sleep of the two nicotine patches in 20 heavy smokers (9 women, 11 men). During each period, polysomnographic recordings were performed from 12 pm to 7 am for two consecutive nights (baseline and treatment nights). Smoking cessation started from 8 pm the day of the baseline sleep recordings, and treatments were applied around 8 am the following morning.
Compared to the 16-h nicotine patch, smokers who received the 24-h nicotine patch experienced significantly less microarousals, a greater proportion of slow wave sleep, a higher REM density and higher rapid eye movement (REM) beta activities.
The results of this study suggest that a 24-h nicotine patch is more efficient than a 16-h nicotine patch to alleviate tobacco withdrawal-induced sleep disturbances.
睡眠障碍是戒烟过程中的常见症状，可能导致戒烟者早期复吸风险增加。本研究旨在比较24小时尼古丁贴片（Nicopatch）和16小时尼古丁贴片（Nicorette）对睡眠的影响。
在短期戒烟期（48小时）内，这项开放标签、随机、两阶段交叉研究比较了两种尼古丁贴片对20名重度吸烟者（9名女性，11名男性）睡眠的影响。在每个阶段，连续两晚（基线期和治疗期）于中午12点至上午7点进行多导睡眠图记录。戒烟从基线睡眠记录当天晚上8点开始，治疗于次日上午8点左右开始。
与16小时尼古丁贴片相比，使用24小时尼古丁贴片的吸烟者微觉醒显著减少，慢波睡眠比例更高，快速眼动睡眠密度更高，快速眼动（REM）期β活动更高。
本研究结果表明，24小时尼古丁贴片在缓解戒烟引起的睡眠障碍方面比16小时尼古丁贴片更有效。
