Sleator Roy D, Hill Colin
Department of Microbiology & Alimentary Pharmabiotic Centre, University College, Cork, Ireland.
Curr Opin Biotechnol. 2006 Apr;17(2):211-6. doi: 10.1016/j.copbio.2006.01.006. Epub 2006 Feb 3.
Pathogenic bacteria have evolved sophisticated strategies to overcome host defences, to interact with the immune system and to interfere with essential host systems. We coin the term 'patho-biotechnology' to describe the exploitation of these valuable traits in biotechnology, medicine and food. This approach shows promise for the development of novel vaccine and drug delivery systems, as well as for the design of more technologically robust and effective probiotic cultures with improved biotechnological and clinical applications. The genetic tractability of Listeria monocytogenes, the availability of the complete genome sequence of this intracellular pathogen, its ability to cope with stress, and its ability to traverse the gastrointestinal tract and induce a strong cellular immune response make L. monocytogenes an ideal model organism for demonstrating the patho-biotechnology concept.
致病细菌已经进化出复杂的策略来克服宿主防御、与免疫系统相互作用并干扰宿主的关键系统。我们创造了“病理生物技术”一词来描述在生物技术、医学和食品领域对这些宝贵特性的利用。这种方法在新型疫苗和药物递送系统的开发方面显示出前景，同时也有助于设计具有更强技术稳定性和有效性、生物技术及临床应用得到改进的益生菌培养物。单核细胞增生李斯特菌的遗传易操作性、该细胞内病原体完整基因组序列的可得性、其应对压力的能力、穿越胃肠道并诱导强烈细胞免疫反应的能力，使得单核细胞增生李斯特菌成为证明病理生物技术概念的理想模式生物。
