信使核糖核酸前体加工及其调控：基因组视角
Pre-messenger RNA processing and its regulation: a genomic perspective.
作者信息
Soller M
机构信息
Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts, 02454, USA.
出版信息
Cell Mol Life Sci. 2006 Apr;63(7-8):796-819. doi: 10.1007/s00018-005-5391-x.
The sequence of entire genomes from higher eukaryotes revealed that an average gene is very large due to the interruption of the coding sequence with large noncoding introns. Introns are co-transcriptionally removed by splicing with great accuracy and fidelity, although contrary to our expectations, currently known signals required for pre-messenger RNA (mRNA) processing are very degenerate and redundant. Furthermore, the vast majority of genes are alternatively processed. A large number of proteins are therefore involved in generating specificity in pre-mRNA processing that requires a dedicated mechanisms to operate at genomic dimensions. In this review I will summarize recent progress in understanding how established principles of pre-mRNA processing extend to genomic dimensions and discuss emerging concepts in coupling of pre-mRNA processing with other nuclear events and nuclear organization.
来自高等真核生物的完整基因组序列显示，由于编码序列被大量非编码内含子打断，平均基因非常大。内含子在共转录过程中通过剪接被极其精确和保真地去除，尽管与我们的预期相反，目前已知的信使核糖核酸前体（mRNA）加工所需的信号非常简并且冗余。此外，绝大多数基因存在可变加工。因此，大量蛋白质参与在前体mRNA加工中产生特异性，这需要专门的机制在基因组层面发挥作用。在这篇综述中，我将总结在理解前体mRNA加工的既定原则如何扩展到基因组层面方面的最新进展，并讨论前体mRNA加工与其他核事件及核组织耦合方面的新兴概念。
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