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炎症诱导的α1-酸性糖蛋白基因变体表达和糖基化变化。对人血清、人肝细胞原代培养物和转基因小鼠的研究。

Inflammation-induced changes in expression and glycosylation of genetic variants of alpha 1-acid glycoprotein. Studies with human sera, primary cultures of human hepatocytes and transgenic mice.

作者信息

van Dijk W, Pos O, van der Stelt M E, Moshage H J, Yap S H, Dente L, Baumann P, Eap C B

机构信息

Department of Medical Chemistry, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands.

出版信息

Biochem J. 1991 Jun 1;276 ( Pt 2)(Pt 2):343-7. doi: 10.1042/bj2760343.

DOI:10.1042/bj2760343
PMID:1646598
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1151097/
Abstract

The relative occurrence of genetic variants of human alpha 1-acid glycoprotein (AGP) in relation to changes in glycosylation was studied in sera of patients with burn injury, media of cytokine-treated primary cultures of human hepatocytes and Hep 3B cells, and sera of transgenic mice expressing the human AGP-A gene. It is concluded (i) that the glycosylation of AGP was not dependent on its genetic expression and (ii) that both the variants determined by the AGP-A gene as well as by the AGP-B/B' genes are increased after inflammation or treatment with interleukins 1 and 6.

摘要

在烧伤患者的血清、经细胞因子处理的人原代肝细胞和Hep 3B细胞培养上清液以及表达人AGP - A基因的转基因小鼠血清中，研究了人α1 - 酸性糖蛋白（AGP）基因变体的相对发生率与糖基化变化的关系。得出的结论是：（i）AGP的糖基化不依赖于其基因表达；（ii）由AGP - A基因以及AGP - B/B'基因决定的变体在炎症或用白细胞介素1和6处理后均增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bae4/1151097/3603fc99809c/biochemj00158-0078-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bae4/1151097/617a26e97adf/biochemj00158-0078-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bae4/1151097/3603fc99809c/biochemj00158-0078-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bae4/1151097/617a26e97adf/biochemj00158-0078-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bae4/1151097/3603fc99809c/biochemj00158-0078-b.jpg

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本文引用的文献

1
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Hoppe Seylers Z Physiol Chem. 1980 Oct;361(10):1567-72. doi: 10.1515/bchm2.1980.361.2.1567.
2
An in vitro bioassay for leukocytic endogenous mediator(s) using cultured rat hepatocytes.一种使用培养的大鼠肝细胞进行白细胞内源性介质体外生物测定法。
Inflammation. 1981 Dec;5(4):275-87. doi: 10.1007/BF00911093.
3
Evidence for alpha-1-acid glycoprotein populations of different pI values after concanavalin A affinity chromatography. Study of their evolution during inflammation in man.
循环外泌体与严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染密切相关。
Front Mol Biosci. 2021 Feb 22;8:632290. doi: 10.3389/fmolb.2021.632290. eCollection 2021.
4
An overview of albumin and alpha-1-acid glycoprotein main characteristics: highlighting the roles of amino acids in binding kinetics and molecular interactions.白蛋白和α-1-酸性糖蛋白主要特性概述：强调氨基酸在结合动力学和分子相互作用中的作用。
Heliyon. 2019 Nov 21;5(11):e02879. doi: 10.1016/j.heliyon.2019.e02879. eCollection 2019 Nov.
5
Genomic evidence for shared common ancestry of East African hunting-gathering populations and insights into local adaptation.东非狩猎采集人群的共同祖先的基因组证据及对当地适应的见解。
Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4166-4175. doi: 10.1073/pnas.1817678116. Epub 2019 Feb 19.
6
Biantennary glycans as well as genetic variants of alpha1-acid glycoprotein control the enantioselectivity and binding affinity of oxybutynin.双触角聚糖以及α1-酸性糖蛋白的基因变体控制着奥昔布宁的对映选择性和结合亲和力。
Pharm Res. 2006 May;23(5):1038-42. doi: 10.1007/s11095-006-9777-8. Epub 2006 May 2.
7
Distinct glycoforms of human alpha1-acid glycoprotein have comparable synthesis rates: a [13C]valine-labelling study in healthy humans.人α1-酸性糖蛋白的不同糖型具有可比的合成速率：一项在健康人体中的[13C]缬氨酸标记研究。
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8
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Pharm Res. 2001 Mar;18(3):389-93. doi: 10.1023/a:1011023518144.
9
The increased potential for the production of inflammatory cytokines by Kupffer cells and splenic macrophages eight days after thermal injury.
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10
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J Exp Med. 1993 Mar 1;177(3):657-66. doi: 10.1084/jem.177.3.657.
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4
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5
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6
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7
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8
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9
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10
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