一株爱泼斯坦-巴尔病毒产生细胞系Akata：细胞系的建立及病毒DNA分析
An Epstein-Barr virus-producer line Akata: establishment of the cell line and analysis of viral DNA.
作者信息
Takada K, Horinouchi K, Ono Y, Aya T, Osato T, Takahashi M, Hayasaka S
机构信息
Department of Microbiology, Nihon University School of Medicine, Tokyo, Japan.
出版信息
Virus Genes. 1991 Apr;5(2):147-56. doi: 10.1007/BF00571929.
An Epstein-Barr virus (EBV)-producer line, designated Akata, was established from a Japanese patient with Burkitt's lymphoma. The Akata line possessed the Burkitt's-type chromosome translocation, t(8q- ; 14q+), and was derived from the tumor cell. Akata cells produced a large quantity of transforming virus upon treatment of cells with anti-immunoglobulin antibodies (Takada, 1984). Southern blot analysis of viral DNA indicated that the Akata EBV is nondefective and more representative of wild-type viruses. Akata cells should be useful as a source of EBV.
一个名为赤羽（Akata）的能产生爱泼斯坦-巴尔病毒（EBV）的细胞系，是从一名患有伯基特淋巴瘤的日本患者身上建立的。赤羽细胞系具有伯基特型染色体易位，t(8q- ; 14q+)，并且源自肿瘤细胞。在用抗免疫球蛋白抗体处理细胞后，赤羽细胞产生大量转化病毒（高田，1984年）。病毒DNA的Southern印迹分析表明，赤羽EBV无缺陷，更具野生型病毒的代表性。赤羽细胞应可作为EBV的一个来源。
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