Nowicki Marek J, Chinchilla Claudia, Corado Livier, Matsuoka Lea, Selby Rick, Steurer Frank, Mone Thomas, Mendez Robert, Aswad Sali
National Institute of Transplantation, Los Angeles, CA 90057, USA.
Transplantation. 2006 Feb 15;81(3):477-9. doi: 10.1097/01.tp.0000195778.08411.b8.
Trypanosoma cruzi, a parasite that causes Chagas' disease, is endemic in parts of Mexico, South America, and Central America. Transmission of T. cruzi infection by solid organ transplantation has been reported in Latin America and recently in the United States. To determine the prevalence of T. cruzi antibodies in Southern California organ donors, 404 samples from deceased organ donors between May 2002 to April 2004 were screened using a qualitative enzyme-linked immunosorbent assay (EIA) and confirmed with an immunofluorescence assay (IFA) available through the Centers for Disease Control (CDC). Six donors were initially reactive by EIA. Three donors were repeatedly reactive after repeat testing and were sent to the CDC for confirmation. One donor (0.25%) had an IFA-confirmed reactivity to anti-T. cruzi antibodies. In areas where there is a high number of immigrants from T. cruzi endemic countries, screening for anti-T. cruzi donor antibodies may be beneficial.
克氏锥虫是一种可引发恰加斯病的寄生虫，在墨西哥部分地区、南美洲和中美洲呈地方性流行。拉丁美洲以及最近在美国均有关于通过实体器官移植传播克氏锥虫感染的报道。为确定南加州器官捐献者中克氏锥虫抗体的流行情况，对2002年5月至2004年4月间已故器官捐献者的404份样本采用定性酶联免疫吸附测定（EIA）进行筛查，并通过疾病控制中心（CDC）提供的免疫荧光测定（IFA）加以确认。6名捐献者最初EIA检测呈阳性反应。3名捐献者在复测后仍反复呈阳性反应，并被送往疾病控制中心进行确认。1名捐献者（0.25%）经IFA确认对抗克氏锥虫抗体呈阳性反应。在来自克氏锥虫流行国家的移民数量众多的地区，筛查捐献者的抗克氏锥虫抗体可能有益。
