灵长类动物中用于多发性硬化症的磁共振成像引导免疫疗法的研发
MRI-guided immunotherapy development for multiple sclerosis in a primate.
作者信息
't Hart Bert A, Smith Paul, Amor Sandra, Strijkers Gustav J, Blezer Erwin L A
机构信息
Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, The Netherlands.
出版信息
Drug Discov Today. 2006 Jan;11(1-2):58-66. doi: 10.1016/S1359-6446(05)03673-1.
Multiple sclerosis is a serious neurological disease that affects 1 in 1000 young adults in Europe and the USA. The development of an effective therapy for this enigmatic disease is plagued by the failure of many treatments to reproduce in patients the promising effects observed in animal models. This review describes a new preclinical model in a non-human primate that might help to bridge the gap between currently used animal models and the patients.
多发性硬化症是一种严重的神经疾病，在欧洲和美国，每1000名年轻人中就有1人受其影响。针对这种神秘疾病的有效疗法的研发面临困境，许多治疗方法在动物模型中显示出有前景的效果，但在患者身上却无法重现。这篇综述描述了一种新的非人类灵长类动物临床前模型，它可能有助于弥合当前使用的动物模型与患者之间的差距。
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