Choi Dongil, Lim Jae Hoon, Lee Kyu Taek, Lee Jong Kyun, Choi Seong Ho, Heo Jin Seok, Jang Kee-Taek, Lee Nam Yong, Kim Seonwoo, Hong Sung-Tae
Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, Ilwon-Dong, Kangnam-Ku, Seoul 135-710, South Korea.
J Hepatol. 2006 Jun;44(6):1066-73. doi: 10.1016/j.jhep.2005.11.040. Epub 2005 Dec 27.
BACKGROUND/AIMS: The authors conducted a hospital-based case-control study to evaluate the role of Clonorchis sinensis infection as a risk factor for the development of cholangiocarcinoma (CC), including extrahepatic CC, in Korea.
Cases of 185 patients with CC (intrahepatic, 51; hilar, 53; and distal extrahepatic, 81) and matched controls underwent stool microscopy, pathological examinations, serologic test for C. sinensis using ELISA, skin test for C. sinensis, radiologic examinations, and interview concerning history of eating raw freshwater fish.
Radiologic evidence of C. sinensis, history of eating raw freshwater fish, and positive serologic result for C. sinensis were found to be related to an increased risk of CC, with the odds ratios (OR)=8.615 (95% confidence interval [CI]=5.045-16.062), OR=2.385 (95% CI=1.527-3.832), and OR=2.272 (95% CI=1.147-4.811), respectively. The risk factors for distal extrahepatic CC were radiologic evidence of C. sinensis (OR=6.571; 95% CI=3.170-15.943) and history of eating raw freshwater fish (OR=2.6; 95% CI=1.294-5.66).
Radiologic evidence of C. sinensis, history of eating raw freshwater fish and positive serologic result for C. sinensis were significantly associated with CC, including extrahepatic CC.
背景/目的：作者开展了一项基于医院的病例对照研究，以评估华支睾吸虫感染作为韩国胆管癌（CC）包括肝外胆管癌发生风险因素的作用。
185例胆管癌患者（肝内胆管癌51例、肝门部胆管癌53例、远端肝外胆管癌81例）及匹配的对照组接受了粪便显微镜检查、病理检查、采用酶联免疫吸附测定法对华支睾吸虫进行的血清学检测、华支睾吸虫皮肤试验、放射学检查以及关于食用生淡水鱼史的访谈。
发现华支睾吸虫的放射学证据、食用生淡水鱼史以及华支睾吸虫血清学检测阳性结果与胆管癌风险增加相关，比值比（OR）分别为8.615（95%置信区间[CI]=5.045 - 16.062）、OR = 2.385（95% CI = 1.527 - 3.832）和OR = 2.272（95% CI = 1.147 - 4.811）。远端肝外胆管癌的风险因素为华支睾吸虫的放射学证据（OR = 6.571；95% CI = 3.170 - 15.943）和食用生淡水鱼史（OR = 2.6；95% CI = 1.294 - 5.66）。
华支睾吸虫的放射学证据、食用生淡水鱼史以及华支睾吸虫血清学检测阳性结果与胆管癌包括肝外胆管癌显著相关。
