Shi Yunliang, Jiang Zhihua, Yang Yichao, Zheng Peiqiu, Wei Haiyan, Lin Yuan, Lv Guoli, Yang Qingli
Institute of Parasitic Disease Prevention and Control, Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, 18, Jinzhou Rd, Nanning, Guangxi, 530028, China.
Hengxian People's Hospital, Nanning, 530300, China.
Parasitol Res. 2017 Oct;116(10):2645-2649. doi: 10.1007/s00436-017-5572-1. Epub 2017 Aug 12.
To evaluate the contributions of Clonorchis sinensis and hepatitis B virus to the development of cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC), C. sinensis and hepatitis B virus infections in 20 clinical liver cancer cases from a C. sinensis- and hepatitis B virus-epidemic region were detected. Eight cases of ICC, 11 cases of HCC and one mixed ICC and HCC case were verified by CT, pathological section and (or) observations during surgery. The C. sinensis infection was detected by stool microscopy and ELISA, and the worms and eggs found during surgery and in pathological sections also allowed for diagnoses. Hepatitis B virus infections were detected by ELISA. In the 20 cases, 18 patients were diagnosed with C. sinensis infections. Eight of the 20 patients were infected with the hepatitis B virus, and seven were co-infected with C. sinensis. In the eight ICC patients, seven were diagnosed with C. sinensis infection, and two had mixed infections with the hepatitis B virus. In the 11 HCC patients, 10 were diagnosed with C. sinensis, four had mixed infections with the hepatitis B virus, and only one HCC patient presented a single infection by the hepatitis B virus. These clinical observations revealed that C. sinensis infection and C. sinensis co-infection with the hepatitis B virus are important factors in ICC and HCC.
为评估华支睾吸虫和乙型肝炎病毒对胆管癌（ICC）和肝细胞癌（HCC）发生发展的作用，对来自华支睾吸虫和乙型肝炎病毒流行区的20例临床肝癌病例检测了华支睾吸虫和乙型肝炎病毒感染情况。通过CT、病理切片及（或）手术中的观察确诊了8例ICC、11例HCC及1例ICC与HCC混合型病例。通过粪便显微镜检查和酶联免疫吸附测定（ELISA）检测华支睾吸虫感染，手术及病理切片中发现的虫体和虫卵也可用于诊断。通过ELISA检测乙型肝炎病毒感染。在这20例病例中，18例患者被诊断为华支睾吸虫感染。20例患者中有8例感染了乙型肝炎病毒，7例同时感染了华支睾吸虫。在8例ICC患者中，7例被诊断为华支睾吸虫感染，2例同时感染了乙型肝炎病毒。在11例HCC患者中，10例被诊断为华支睾吸虫感染，4例同时感染了乙型肝炎病毒，只有1例HCC患者为单纯乙型肝炎病毒感染。这些临床观察结果表明，华支睾吸虫感染以及华支睾吸虫与乙型肝炎病毒的共同感染是ICC和HCC的重要影响因素。
