Garzelli C, Bazzichi A
Department of Biomedicine, University of Pisa, Italy.
Experientia. 1991 Jul 15;47(7):731-4. doi: 10.1007/BF01958829.
Self-stimulatory growth factors, produced by a human Epstein-Barr virus (EBV)-positive lymphoblastoid B cell line, named BA-D10-4, have been tested for the capacity to induce DNA synthesis in various human and animal cell lines, including lymphoid, either EBV-positive or EBV-negative, and non-lymphoid cell lines. It has been found that BA-D10-4 cells produce growth factors which seem to be essential for their sustained proliferation in vitro, and which increase DNA synthesis in different primate lymphoid cells, independently of the presence of the EBV genome and of the lymphocyte lineage.
由一株名为BA-D10-4的人爱泼斯坦-巴尔病毒（EBV）阳性淋巴母细胞B细胞系产生的自我刺激生长因子，已针对其在各种人和动物细胞系（包括EBV阳性或EBV阴性的淋巴样细胞系以及非淋巴样细胞系）中诱导DNA合成的能力进行了测试。已发现BA-D10-4细胞产生的生长因子似乎对其体外持续增殖至关重要，并且这些生长因子可增加不同灵长类淋巴样细胞中的DNA合成，而与EBV基因组的存在和淋巴细胞谱系无关。
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