Langård S, Norseth T
Br J Ind Med. 1975 Feb;32(1):62-5. doi: 10.1136/oem.32.1.62.
A cohort study of the incidence of bronchial cancer in male workers in a small company producing chromate pigments is presented. Altogether 133 workers had been employed by the company from the time production was started in 1948 until the end of 1972. Workers with more than three years employment were included in the study, and three cases of bronchial carcinoma were found among the 24 workers who fulfilled this requirement. Based on the data of the Cancer Registry of Norway the risk of bronchial cancer for a corresponding group of the general population was found to be 0.079, which gives a risk ratio for exposed workers of approximately 38. The average age of the cancer patients was as low as 50 years at the time of diagnosis. All workers in the company had been exposed mainly to zinc chromate dust, and the exposure levels of the workers developing bronchial cancers had probably been from 0-5 to 1-5 mg Cr/m-3 for six to nine years. Two of the three patients were smokers. It is assumed that exposure to chromate pigments, and probably to zinc chromate, may be related to the increased incidence of bronchial cancer in this group of workers. The possibility of a contributing effect of tobacco smoking in at least two of the three cases cannot be ruled out.
本文介绍了一项针对一家生产铬酸盐颜料的小公司男性工人支气管癌发病率的队列研究。从1948年公司开始生产到1972年底，该公司共雇佣了133名工人。工作三年以上的工人被纳入研究，在满足这一条件的24名工人中发现了3例支气管癌病例。根据挪威癌症登记处的数据，相应的普通人群组患支气管癌的风险为0.079，这使得暴露工人的风险比约为38。癌症患者确诊时的平均年龄低至50岁。该公司所有工人主要接触铬酸锌粉尘，患支气管癌的工人的接触水平可能在0.5至1.5毫克铬/立方米之间，持续了6至9年。三名患者中有两名吸烟。据推测，接触铬酸盐颜料，可能还有铬酸锌，可能与该组工人支气管癌发病率的增加有关。不能排除吸烟在三例病例中至少两例中起促进作用的可能性。
