Ronning Catherine M, Fedorova Natalie D, Bowyer Paul, Coulson Richard, Goldman Gustavo, Kim H Stanley, Turner Geoffrey, Wortman Jennifer R, Yu Jiujiang, Anderson Michael J, Denning David W, Nierman William C
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
Rev Iberoam Micol. 2005 Dec;22(4):223-8. doi: 10.1016/s1130-1406(05)70047-4.
Aspergillus fumigatus is a filamentous fungal saprophyte that is ubiquitous in the environment. It is also a human pathogen and induces allergenic response, negatively impacting health care and associated costs significantly around the world. Much of the basic biology of this organism is only poorly understood, but the recent completion and publication of its genome sequence provides an excellent tool for researchers to gain insight into these processes. In this review we will summarize some of the more salient features revealed by analysis of the genome, including the search for candidate pathogenicity genes and the switch to a pathogenic lifestyle, allergen proteins, DNA repair, secondary metabolite gene clusters that produce compounds both useful and toxic, a theoretical capability of this asexual organism to reproduce sexually, signalling, and transcription. A. fumigatus was compared with the food biotechnology fungus Aspergillus oryzae and sexual fungus Aspergillus nidulans, as well as other fungi, in an attempt to discern key differences between these organisms.
烟曲霉是一种丝状真菌腐生菌，在环境中广泛存在。它也是一种人类病原体，会引发过敏反应，在全球范围内对医疗保健及相关成本产生重大负面影响。人们对这种生物体的许多基础生物学知识了解甚少，但最近其基因组序列的完成和公布为研究人员深入了解这些过程提供了一个绝佳工具。在这篇综述中，我们将总结基因组分析揭示的一些更为显著的特征，包括寻找候选致病基因和向致病生活方式的转变、过敏原蛋白、DNA修复、产生有用和有毒化合物的次级代谢产物基因簇、这种无性生物体进行有性繁殖的理论能力、信号传导和转录。为了辨别这些生物体之间的关键差异，将烟曲霉与食品生物技术真菌米曲霉和有性真菌构巢曲霉以及其他真菌进行了比较。
