Leinweber Felix C, Eijkel Jan C T, Bomer Johan G, van den Berg Albert
MESA Institute for Nanotechnology, BIOS/ Lab-on-a-Chip Group, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.
Anal Chem. 2006 Mar 1;78(5):1425-34. doi: 10.1021/ac051615n.
A continuous flow microfluidic demixing process is realized. It utilizes high external electrical fields that are applied over electrically floating noble metal electrodes in an otherwise straight microchannel. The process converts axial electrical potential gradients into lateral molecular selective transport via a structure oriented ensemble of numerous electrodes. While the individual electrodes locally modify the electrolyte distribution by nonlinear electrokinetic effects and concentration polarization, the directed orientation of the electrode array combines the individual polarization zones to a dedicated molecular enrichment against the generated concentration gradient. A homogeneously concentrated electrolyte can be separated into arbitrarily shaped laminae of increased and depleted concentration by the presented microfluidic demixer.
实现了一种连续流动微流体混合过程。该过程利用施加在直微通道中电浮贵金属电极上的高外部电场。该过程通过大量电极的定向排列结构将轴向电势梯度转化为横向分子选择性传输。虽然单个电极通过非线性电动效应和浓度极化局部改变电解质分布，但电极阵列的定向排列将各个极化区组合成一个专门的分子富集区，以对抗产生的浓度梯度。通过所提出的微流体混合器，可以将均匀浓缩的电解质分离成浓度增加和减少的任意形状的薄层。
