Vasto Sonya, Malavolta Marco, Pawelec Graham
Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, Italia.
Immun Ageing. 2006 Feb 24;3:2. doi: 10.1186/1742-4933-3-2.
Longitudinal studies are defining progressive alterations to the immune system associated with increased mortality in the very elderly. Many of these changes are exacerbated by or even caused by chronic T cell stimulation by persistent antigen, particularly from Cytomegalovirus. The composition of T cell subsets, their functional integrity and representation in the repertoire are all markedly influenced by age and by CMV. How these findings relate to epidemiological, functional, genetic, genomic and proteomic studies of human T cell immunosenescence was the subject of intense debate at an international conference held just before Christmas 2005 in the Black Forest.
纵向研究正在明确与高龄老人死亡率增加相关的免疫系统的渐进性改变。其中许多变化因持续存在的抗原，特别是巨细胞病毒对T细胞的慢性刺激而加剧，甚至由其引起。T细胞亚群的组成、其功能完整性以及在库中的表现均受到年龄和巨细胞病毒的显著影响。这些发现与人类T细胞免疫衰老的流行病学、功能、遗传、基因组和蛋白质组学研究之间的关系，是2005年圣诞节前夕在黑森林举行的一次国际会议上激烈辩论的主题。
