Bagg J, Perry K R, Parry J V, Mortimer P P, Peters T J
Department of Oral Surgery, Medicine and Pathology, Dental School, Heath Park, Cardiff, Wales.
Arch Oral Biol. 1991;36(3):221-6. doi: 10.1016/0003-9969(91)90089-d.
An antibody-capture radioimmunoassay was used to measure levels of IgG class antibodies to rubella and hepatitis A viruses in serum and saliva of 30 edentulous, 30 partially dentate and 31 dentate individuals. The prevalence of seropositivity for rubella was 98.9 per cent and for hepatitis A 73.6 per cent. The serum reactivities were generally greater than those for saliva. There were 8 false-negative results for saliva out of the 182 tests performed, of which 4 were in the edentulous group, 3 in the partially dentate and 1 in the dentate group. For both rubella and hepatitis A virus antibodies the (geometric) mean ratios between the saliva and serum reactivities were similar across the three dental groups. The values for sensitivity, specificity and positive predictive value suggest that assay of saliva for antiviral IgG antibody is a satisfactory technique regardless of dental status.
采用抗体捕获放射免疫分析法，检测了30名无牙颌个体、30名部分牙列缺损个体和31名有牙列个体血清及唾液中抗风疹病毒和甲型肝炎病毒IgG类抗体水平。风疹血清阳性率为98.9%，甲型肝炎为73.6%。血清反应性通常高于唾液。在进行的182次检测中，唾液检测有8例假阴性结果，其中无牙颌组4例，部分牙列缺损组3例，有牙列组1例。对于风疹和甲型肝炎病毒抗体，三个牙列组唾液与血清反应性的（几何）平均比值相似。敏感性、特异性和阳性预测值表明，无论牙列状况如何，检测唾液中的抗病毒IgG抗体都是一种令人满意的技术。
