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巨噬细胞移动抑制因子在乙型肝炎病毒特异性细胞毒性T淋巴细胞诱导的肝损伤中的作用。

Role of macrophage migration inhibitory factor in hepatitis B virus-specific cytotoxic-T-lymphocyte-induced liver injury.

作者信息

Kimura Kiminori, Nagaki Masahito, Nishihira Jun, Satake Shinichi, Kuwata Kazuo, Moriwaki Hisataka

机构信息

First Department of Internal Medicine, Gifu University School of Medicine, 1-1 Yanagido, Gifu-shi Gifu 501-1194, Japan.

出版信息

Clin Vaccine Immunol. 2006 Mar;13(3):415-9. doi: 10.1128/CVI.13.3.415-419.2006.

DOI:10.1128/CVI.13.3.415-419.2006
PMID:16522786
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1391960/
Abstract

Macrophage migration inhibitory factor (MIF) plays a pivotal role in the development of various inflammatory diseases. Here, we found that anti-mouse MIF antibody treatment reduced liver injury and inflammatory cell infiltration into the liver after injection of antigen-specific cytotoxic T lymphocytes into hepatitis B virus transgenic mice.

摘要

巨噬细胞移动抑制因子（MIF）在多种炎症性疾病的发展中起关键作用。在此，我们发现，在将抗原特异性细胞毒性T淋巴细胞注射到乙型肝炎病毒转基因小鼠体内后，抗小鼠MIF抗体治疗减轻了肝脏损伤以及炎性细胞向肝脏的浸润。

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Role of macrophage migration inhibitory factor in hepatitis B virus-specific cytotoxic-T-lymphocyte-induced liver injury.巨噬细胞移动抑制因子在乙型肝炎病毒特异性细胞毒性T淋巴细胞诱导的肝损伤中的作用。
Clin Vaccine Immunol. 2006 Mar;13(3):415-9. doi: 10.1128/CVI.13.3.415-419.2006.
2
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本文引用的文献

1
Blockade of neutrophil elastase attenuates severe liver injury in hepatitis B transgenic mice.抑制中性粒细胞弹性蛋白酶可减轻乙型肝炎转基因小鼠的严重肝损伤。
J Virol. 2005 Dec;79(24):15142-50. doi: 10.1128/JVI.79.24.15142-15150.2005.
2
Reduced leukocyte-endothelial cell interactions in the inflamed microcirculation of macrophage migration inhibitory factor-deficient mice.巨噬细胞移动抑制因子缺陷小鼠炎症性微循环中白细胞与内皮细胞相互作用的减少
Arthritis Rheum. 2004 Sep;50(9):3023-34. doi: 10.1002/art.20470.
3
Leflunomide protects from T-cell-mediated liver injury in mice through inhibition of nuclear factor kappaB.来氟米特通过抑制核因子κB保护小鼠免受T细胞介导的肝损伤。
Hepatology. 2004 Nov;40(5):1160-9. doi: 10.1002/hep.20438.
4
Macrophage migration inhibitory factor: a regulator of innate immunity.巨噬细胞移动抑制因子：一种先天性免疫的调节因子。
Nat Rev Immunol. 2003 Oct;3(10):791-800. doi: 10.1038/nri1200.
5
Macrophage migration inhibitory factor is a critical mediator of severe acute pancreatitis.巨噬细胞移动抑制因子是重症急性胰腺炎的关键介质。
Gastroenterology. 2003 Mar;124(3):725-36. doi: 10.1053/gast.2003.50099.
6
Activated intrahepatic antigen-presenting cells inhibit hepatitis B virus replication in the liver of transgenic mice.活化的肝内抗原呈递细胞抑制转基因小鼠肝脏中的乙型肝炎病毒复制。
J Immunol. 2002 Nov 1;169(9):5188-95. doi: 10.4049/jimmunol.169.9.5188.
7
Interleukin-18 inhibits hepatitis B virus replication in the livers of transgenic mice.白细胞介素-18抑制转基因小鼠肝脏中的乙型肝炎病毒复制。
J Virol. 2002 Nov;76(21):10702-7. doi: 10.1128/jvi.76.21.10702-10707.2002.
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Cytokine-sensitive replication of hepatitis B virus in immortalized mouse hepatocyte cultures.乙型肝炎病毒在永生化小鼠肝细胞培养物中的细胞因子敏感性复制
J Virol. 2002 Jun;76(11):5646-53. doi: 10.1128/jvi.76.11.5646-5653.2002.
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Ubiquitous production of macrophage migration inhibitory factor by human gastric and intestinal epithelium.人胃和肠上皮广泛产生巨噬细胞移动抑制因子。
Gastroenterology. 2002 Mar;122(3):667-80. doi: 10.1053/gast.2002.31891.
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Nat Immunol. 2001 Nov;2(11):1061-6. doi: 10.1038/ni720.