el Azazi M, Samuelsson A, Linde A, Forsgren M
Department of Ophthalmology, Huddinge University Hospital, Sweden.
Am J Ophthalmol. 1991 Jul 15;112(1):76-82. doi: 10.1016/s0002-9394(14)76217-8.
Viruses of the herpesvirus family cause acute retinal necrosis syndrome, a devastating necrotic retinitis in immunocompetent individuals. Direct proof of the viral origin of this disease may be obtained by demonstration of the virus, viral antigens, or viral DNA in biopsy specimens of retinas. In search of alternative diagnostic methods, we analyzed cerebrospinal fluid and serum with enzyme-linked immunosorbent assays for virus-specific antibody activity. Intrathecally produced viral antibodies were found in three consecutive patients with acute retinal necrosis syndrome: herpes simplex type 2 in a 30-year-old woman with a history of suspected neonatal herpes encephalitis, herpes simplex type 1 in a 35-year-old man, and varicella-zoster virus activity in a 62-year-old woman. None of the patients had clinical signs indicating an acute disorder in the central nervous system. This serologic approach seems to be of value for the diagnosis of an associated intracerebral viral infection in cases of acute retinal necrosis syndrome.
疱疹病毒科病毒可引起急性视网膜坏死综合征，这是一种在免疫功能正常个体中具有破坏性的坏死性视网膜炎。通过在视网膜活检标本中证实病毒、病毒抗原或病毒DNA，可获得该病病毒起源的直接证据。为寻找替代诊断方法，我们采用酶联免疫吸附试验分析脑脊液和血清中的病毒特异性抗体活性。在3例连续的急性视网膜坏死综合征患者中发现了鞘内产生的病毒抗体：1例30岁有疑似新生儿疱疹性脑炎病史的女性为2型单纯疱疹病毒，1例35岁男性为1型单纯疱疹病毒，1例62岁女性为水痘-带状疱疹病毒活性。所有患者均无提示中枢神经系统急性疾病的临床体征。这种血清学方法对于诊断急性视网膜坏死综合征病例中的相关脑内病毒感染似乎具有价值。
