Normén L, Ellegård L, Janssen H-G, Steenbergen H, Trautwein E, Andersson H
Dept of Clinical Nutrition, Göteborg University, Göteborg, Sweden.
Eur J Nutr. 2006 Mar;45(3):165-70. doi: 10.1007/s00394-006-0578-y. Epub 2006 Mar 21.
Hydrolysis of phytosterol ester (PSTE) and phytostanol ester (PSTA) during fat digestion is not well characterised under controlled dietary conditions.
The main aims of this study were therefore to quantify the PSTE and PSTA hydrolysis after gut passage and to assess whether or not PSTE and PSTA induce fat malabsorption by measuring the fatty acid excretion following PSTE/PSTA consumption.
Ileostomy subjects (n = 7) were investigated in a randomised crossover study with one control and two intervention periods, when either 2.5 g of PSTE or PSTA corresponding to 1.5 g free sterol or stanol equivalents were added to a controlled diet. Ileostomy bags were collected and immediately frozen for analysis of nutrients, fatty acids and sterols.
The study showed that 88.4 +/- 5.9% PSTE and 85.7 +/- 6.5% PSTA were hydrolysed following small bowel passage in the ileostomy subjects. The total excretion of fatty acids was similar in all three periods.
A majority of the 2.5 g PSTE and PSTA was hydrolysed during small bowel passage,which did not affect fat absorption as indicated by similar excretions of fatty acids in all periods. Consumption of increasing amounts of esterified phytosterols and phytostanols from enriched food formats should thereby have no adverse effects in this regard.
在可控饮食条件下，脂肪消化过程中植物甾醇酯（PSTE）和植物甾烷醇酯（PSTA）的水解情况尚未得到充分表征。
因此，本研究的主要目的是量化肠道通过后PSTE和PSTA的水解情况，并通过测量食用PSTE/PSTA后脂肪酸排泄量来评估PSTE和PSTA是否会导致脂肪吸收不良。
对回肠造口术患者（n = 7）进行随机交叉研究，包括一个对照期和两个干预期，在对照期，向控制饮食中添加2.5 g PSTE或PSTA，分别相当于1.5 g游离甾醇或甾烷醇当量。收集回肠造口袋并立即冷冻，用于分析营养成分、脂肪酸和甾醇。
研究表明，回肠造口术患者小肠通过后，88.4±5.9%的PSTE和85.7±6.5%的PSTA被水解。三个时期的脂肪酸总排泄量相似。
2.5 g PSTE和PSTA在小肠通过过程中大部分被水解，这并不影响脂肪吸收，所有时期脂肪酸排泄量相似表明了这一点。因此，从强化食品形式中摄入越来越多的酯化植物甾醇和植物甾烷醇在这方面应该没有不良影响。
