Wu Changfeng, Szymanski Craig, McNeill Jason
Department of Chemistry, Center for Optical Materials Science and Engineering Technologies, Clemson University, Clemson, South Carolina 29634, USA.
Langmuir. 2006 Mar 28;22(7):2956-60. doi: 10.1021/la060188l.
A facile method has been developed to prepare aqueous dispersions of encapsulated conjugated polymer nanoparticles exhibiting high fluorescence brightness. Salient features of the nanoparticles include their small diameter and spherical morphology. Encapsulation of the nanoparticles with a silica shell reduces the rate of photooxidation and allows facile attachment of functional groups for subsequent bioconjugation and nanoparticle assembly. Functionalization of the nanoparticle with amine groups followed by the addition of Au nanoparticles resulted in the formation of nanoparticle assemblies, as evidenced by the efficient quenching of the conjugated polymer fluorescence by the Au nanoparticles.
已开发出一种简便方法来制备具有高荧光亮度的包封共轭聚合物纳米粒子的水分散体。这些纳米粒子的显著特征包括其小直径和球形形态。用二氧化硅壳包封纳米粒子可降低光氧化速率，并便于连接官能团以用于后续的生物共轭和纳米粒子组装。用胺基对纳米粒子进行功能化，然后添加金纳米粒子，导致形成纳米粒子组装体，金纳米粒子对共轭聚合物荧光的有效淬灭证明了这一点。
