Boffetta Paolo, Hashibe Mia, La Vecchia Carlo, Zatonski Witold, Rehm Jürgen
International Agency for Research on Cancer, Lyon, France.
Int J Cancer. 2006 Aug 15;119(4):884-7. doi: 10.1002/ijc.21903.
We estimated the number of cancer cases and deaths attributable to alcohol drinking in 2002 by sex and WHO subregion, based on relative risks of cancers of the oral cavity, pharynx, esophagus, liver, colon, rectum, larynx and female breast obtained from recent meta- and pooled analyses and data on prevalence of drinkers obtained from the WHO Global Burden of Disease project. A total of 389,100 cases of cancer are attributable to alcohol drinking worldwide, representing 3.6% of all cancers (5.2% in men, 1.7% in women). The corresponding figure for mortality is 232,900 deaths (3.5% of all cancer deaths). This proportion is particularly high among men in Central and Eastern Europe. Among women, breast cancer comprises 60% of alcohol-attributable cancers. Although our estimates are based on simplified assumptions, the burden of alcohol-associated cancer appears to be substantial and needs to be considered when making public health recommendations on alcohol drinking.
我们根据近期的荟萃分析和汇总分析得出的口腔癌、咽癌、食管癌、肝癌、结肠癌、直肠癌、喉癌及女性乳腺癌的相对风险，以及世界卫生组织全球疾病负担项目提供的饮酒者患病率数据，按性别和世界卫生组织次区域估算了2002年因饮酒导致的癌症病例数和死亡数。全球共有389,100例癌症病例可归因于饮酒，占所有癌症病例的3.6%（男性为5.2%，女性为1.7%）。相应的死亡人数为232,900例（占所有癌症死亡病例的3.5%）。这一比例在中欧和东欧男性中尤其高。在女性中，乳腺癌占酒精所致癌症的60%。尽管我们是基于简化假设进行估算，但酒精相关癌症的负担似乎相当大，在就饮酒问题提出公共卫生建议时需要予以考虑。
