受扩散影响的配体与细胞表面受体结合的时间依赖性速率。
Time dependent rate of diffusion-influenced ligand binding to receptors on cell surfaces.
作者信息
Zwanzig R, Szabo A
机构信息
Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892.
出版信息
Biophys J. 1991 Sep;60(3):671-8. doi: 10.1016/S0006-3495(91)82096-3.
Abstract
The theory of the kinetics of binding of ligands to a sphere partially covered by receptors is extended to provide the full time dependence of the reactive flux. The ligands diffuse to the receptors; the receptors are either fully or partially absorbing. The total flux into the sphere with many receptors is expressed analytically in terms of the flux into a single isolated receptor on the sphere. At steady state, the Berg-Purcell formula is generalized to the case where the binding to a single receptor is only partially diffusion controlled. At short times, the receptors behave independently and the total flux is the sum of the fluxes to the isolated receptors.
摘要
配体与部分被受体覆盖的球体结合的动力学理论得到扩展，以给出反应通量的完整时间依赖性。配体扩散至受体；受体可以是完全吸收或部分吸收的。具有多个受体的球体的总通量通过球体上单个孤立受体的通量进行解析表示。在稳态下，Berg-Purcell公式被推广到单个受体的结合仅部分受扩散控制的情况。在短时间内，受体独立起作用，总通量是孤立受体通量之和。
相似文献
1
Time dependent rate of diffusion-influenced ligand binding to receptors on cell surfaces.受扩散影响的配体与细胞表面受体结合的时间依赖性速率。
Biophys J. 1991 Sep;60(3):671-8. doi: 10.1016/S0006-3495(91)82096-3.
2
Rate constant for diffusion-influenced ligand binding to receptors of arbitrary shape on a cell surface.扩散影响下配体与细胞表面任意形状受体结合的速率常数。
J Chem Phys. 2004 Jul 15;121(3):1562-5. doi: 10.1063/1.1763137.
3
Ligand binding in a spherical region randomly crowded by receptors.配体在受体随机拥挤的球形区域内的结合。
Phys Biol. 2013 Aug;10(4):045009. doi: 10.1088/1478-3975/10/4/045009. Epub 2013 Aug 2.
4
Diffusion-controlled ligand binding to spheres partially covered by receptors: an effective medium treatment.扩散控制的配体与部分被受体覆盖的球体的结合：一种有效介质处理方法。
Proc Natl Acad Sci U S A. 1990 Aug;87(15):5856-7. doi: 10.1073/pnas.87.15.5856.
5
Approximating the effects of diffusion on reversible reactions at the cell surface: ligand-receptor kinetics.近似扩散对细胞表面可逆反应的影响：配体-受体动力学
Biophys J. 1995 Apr;68(4):1222-30. doi: 10.1016/S0006-3495(95)80298-5.
6
Self-consistent theory of reversible ligand binding to a spherical cell.球形细胞可逆配体结合的自洽理论
Phys Biol. 2008 Jan 8;4(4):344-54. doi: 10.1088/1478-3975/4/4/010.
7
Analysis of intracellular receptor/ligand sorting. Calculation of mean surface and bulk diffusion times within a sphere.细胞内受体/配体分选分析。计算球体内的平均表面扩散时间和整体扩散时间。
Biophys J. 1986 Aug;50(2):295-305. doi: 10.1016/S0006-3495(86)83463-4.
8
A Monte Carlo study of the dynamics of G-protein activation.G蛋白激活动力学的蒙特卡罗研究。
Biophys J. 1994 Sep;67(3):1345-57. doi: 10.1016/S0006-3495(94)80606-X.
9
Comparison of two compartmental models for describing receptor ligand kinetics and receptor availability in multiple injection PET studies.两种房室模型在多次注射正电子发射断层扫描（PET）研究中描述受体-配体动力学和受体可利用性的比较
J Cereb Blood Flow Metab. 1996 Sep;16(5):841-53. doi: 10.1097/00004647-199609000-00009.
10
Probability of autocrine ligand capture by cell-surface receptors: implications for ligand secretion measurements.细胞表面受体捕获自分泌配体的概率：对配体分泌测量的影响
J Comput Biol. 1994 Spring;1(1):15-23. doi: 10.1089/cmb.1994.1.15.
引用本文的文献
1
Boundary Homogenization and Numerical Modeling of Solute Transport Across the Blood-Brain Barrier.血脑屏障溶质转运的边界均匀化与数值模拟
bioRxiv. 2025 Jul 3:2025.07.01.662658. doi: 10.1101/2025.07.01.662658.
2
Revising Berg-Purcell for finite receptor kinetics.针对有限受体动力学修正伯格 - 珀塞尔模型。
Biophys J. 2021 Jun 1;120(11):2237-2248. doi: 10.1016/j.bpj.2021.03.021. Epub 2021 Mar 29.
3
Boundary homogenization for a sphere with an absorbing cap of arbitrary size.球体带任意大小吸收帽的边界均匀化。
J Chem Phys. 2016 Dec 7;145(21):214101. doi: 10.1063/1.4968598.
4
Note: Boundary homogenization for a circle with periodic absorbing arcs. Exact expression for the effective trapping rate.注意：具有周期性吸收弧的圆的边界均匀化。有效捕获率的精确表达式。
J Chem Phys. 2015 Dec 14;143(22):226101. doi: 10.1063/1.4936866.
5
Trapping of diffusing particles by striped cylindrical surfaces. Boundary homogenization approach.条纹圆柱面对扩散粒子的捕获。边界均匀化方法。
J Chem Phys. 2015 Jun 21;142(23):234902. doi: 10.1063/1.4922444.
6
Trapping by clusters of channels, receptors, and transporters: quantitative description.通道、受体和转运体簇的捕获：定量描述。
Biophys J. 2014 Feb 4;106(3):500-9. doi: 10.1016/j.bpj.2013.12.015.
7
A computational kinetic model of diffusion for molecular systems.分子系统扩散的计算动力学模型。
J Chem Phys. 2013 Sep 28;139(12):121929. doi: 10.1063/1.4820876.
8
Effect of ligand diffusion on occupancy fluctuations of cell-surface receptors.配体扩散对细胞表面受体占据波动的影响。
J Chem Phys. 2013 Sep 28;139(12):121910. doi: 10.1063/1.4816105.
9
Influence of neighboring reactive particles on diffusion-limited reactions.相邻反应粒子对扩散限制反应的影响。
J Chem Phys. 2013 Jul 28;139(4):044117. doi: 10.1063/1.4816522.
10
Nutrient shielding in clusters of cells.细胞簇中的营养屏蔽
Phys Rev E Stat Nonlin Soft Matter Phys. 2013 Jun;87(6):062703. doi: 10.1103/PhysRevE.87.062703. Epub 2013 Jun 10.
本文引用的文献
1
Role of diffusion in ligand binding to macromolecules and cell-bound receptors.扩散在配体与大分子及细胞结合受体结合中的作用。
Biophys J. 1982 Oct;40(1):33-9. doi: 10.1016/S0006-3495(82)84455-X.
2
Time-dependent ligand current into a saturating cell performing chemoreception.进入进行化学感受的饱和细胞的时间依赖性配体电流。
Biophys Chem. 1988 Sep;31(3):317-24. doi: 10.1016/0301-4622(88)80038-3.
3
Diffusion-controlled ligand binding to spheres partially covered by receptors: an effective medium treatment.扩散控制的配体与部分被受体覆盖的球体的结合：一种有效介质处理方法。
Proc Natl Acad Sci U S A. 1990 Aug;87(15):5856-7. doi: 10.1073/pnas.87.15.5856.
4
Physics of chemoreception.化学感受的物理学
Biophys J. 1977 Nov;20(2):193-219. doi: 10.1016/S0006-3495(77)85544-6.
Zotero 插件