Manner Hendrik, May Andrea, Nachbar Lars, Ell Christian
Department of Internal Medicine II, HSK Wiesbaden (Teaching Hospital of the University of Mainz), Wiesbaden, Germany.
Am J Gastroenterol. 2006 May;101(5):1152-4. doi: 10.1111/j.1572-0241.2006.00558.x.
Meckel's diverticulum (MD) occurs in 2-3% of the population. Although the clinical, histopathologic, and radiologic features of the complications of MD are well known, the diagnosis may be difficult before surgery.
Three patients (age 22-34 yr, two women) presenting with gastrointestinal (GI) bleeding of obscure origin underwent multiple endoscopic and radiologic tests including capsule endoscopy and Tc-99m pertechnetate scintigraphy before push-and-pull enteroscopy using a double-balloon technique (double-balloon enteroscopy). Double-balloon enteroscopy was performed in all three patients using oral and anal approaches to evaluate the entire intestine. In one case, MD was detected using the oral route; the diagnosis was confirmed using the anal approach. In two patients, the lumen of MD was disclosed using the anal route. No procedure-related complications occurred. Push-and-pull enteroscopy was the only nonsurgical procedure that provided a precise diagnosis. All patients underwent surgical resection of the diverticulum. In one case, ectopic gastric tissue was found histologically. No further bleeding occurred during follow-up (6-9 months).
Keeping the low sensitivity of Tc-99m scintigraphy in the adult population in mind, double-balloon enteroscopy might be the modality of choice in young adult patients with acute recurrent GI bleeding of obscure origin and a suspected diagnosis of MD.
梅克尔憩室(MD)在2%至3%的人群中出现。尽管MD并发症的临床、组织病理学和放射学特征已为人熟知,但术前诊断可能困难。
三名不明原因胃肠道(GI)出血患者(年龄22 - 34岁,两名女性)在使用双气囊技术进行推拉式小肠镜检查(双气囊小肠镜)前,接受了包括胶囊内镜和锝-99m高锝酸盐闪烁扫描在内的多次内镜和放射学检查。所有三名患者均采用经口和经肛门途径进行双气囊小肠镜检查以评估整个肠道。其中一例经口途径发现MD;经肛门途径确诊。两例患者经肛门途径发现MD腔。未发生与操作相关的并发症。推拉式小肠镜是唯一能提供精确诊断的非手术方法。所有患者均接受了憩室手术切除。其中一例组织学检查发现异位胃组织。随访期间(6 - 9个月)未再发生出血。
鉴于锝-99m闪烁扫描在成人人群中的低敏感性,双气囊小肠镜可能是病因不明的急性复发性GI出血且疑似MD诊断的年轻成年患者的首选检查方式。