Fleckenstein Kurt B, Cuenin Michael F, Peacock Mark E, Billman Michael A, Swiec Gary D, Buxton Thomas B, Singh Baldev B, McPherson James C
U.S. Army, Fort Bragg, NC, USA.
J Periodontol. 2006 Jan;77(1):39-45. doi: 10.1902/jop.2006.77.1.39.
Bony defects caused by periodontitis are often treated by regenerative therapy using autografts and/or allografts. Alloplasts, such as hydroxyapatite or ceramics, are also used as osteoconductive materials that serve as a scaffold for new bony ingrowth. The purpose of this study was to determine the effect of hydroxyapatite tricalcium phosphate (HA-TCP) on osseous repair in the rat calvarium.
Forty-four adult male Harlan Sprague-Dawley rats were assigned to one of four treatment groups: HA-TCP macroporous disk, HA-TCP microporous disk, HA-TCP granules, and demineralized freeze-dried bone (DFDB). The materials were placed into 8-mm calvarial critical-size defects (CSD). Calvariae were harvested at 10 weeks post-surgery and evaluated histomorphometrically.
The DFDB group had significantly (P <0.05) more new bone formation (47%) than any other group. The HA-TCP macroporous disk group had significantly (P <0.05) more new bone formation (19.7%) than the HA-TCP microporous disk (8.5%) or HA-TCP granule (6.9%) groups.
The HA-TCP macroporous disk may elicit significant new bone formation due to its rigid space-maintaining scaffold and pore size for vascular ingrowth. It is well tolerated by host tissues and may be a suitable carrier for growth factors.
牙周炎导致的骨缺损通常采用自体移植和/或异体移植的再生疗法进行治疗。同种异体骨，如羟基磷灰石或陶瓷，也被用作骨传导材料，作为新骨向内生长的支架。本研究的目的是确定磷酸三钙羟基磷灰石（HA-TCP）对大鼠颅骨骨修复的影响。
44只成年雄性哈兰·斯普拉格-道利大鼠被分配到四个治疗组之一：HA-TCP大孔盘、HA-TCP微孔盘、HA-TCP颗粒和脱矿冻干骨（DFDB）。将这些材料放入8毫米的颅骨临界尺寸缺损（CSD）中。术后10周采集颅骨并进行组织形态计量学评估。
DFDB组的新骨形成量（47%）显著高于其他任何组（P<0.05）。HA-TCP大孔盘组的新骨形成量（19.7%）显著高于HA-TCP微孔盘组（8.5%）和HA-TCP颗粒组（6.9%）（P<0.05）。
HA-TCP大孔盘因其刚性的空间维持支架和适合血管向内生长的孔径，可能会引发显著的新骨形成。它能被宿主组织良好耐受，可能是生长因子的合适载体。
