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在大鼠颅骨骨缺损模型中使用硅取代珊瑚羟基磷灰石和β-磷酸三钙混合物进行骨再生

Bone Regeneration Using a Mixture of Silicon-Substituted Coral HA and β-TCP in a Rat Calvarial Bone Defect Model.

作者信息

Roh Jiyeon, Kim Ji-Youn, Choi Young-Muk, Ha Seong-Min, Kim Kyoung-Nam, Kim Kwang-Mahn

机构信息

BK21 PLUS Project, Yonsei University College of Dentistry, Seoul 03722, Korea.

Department and Research Institute of Dental Biomaterials and Bioengineering, Yonsei University College of Dentistry, Seoul 03722, Korea.

出版信息

Materials (Basel). 2016 Feb 6;9(2):97. doi: 10.3390/ma9020097.

DOI:10.3390/ma9020097
PMID:28787903
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5456508/
Abstract

The demand of bone graft materials has been increasing. Among various origins of bone graft materials, natural coral composed of up to 99% calcium carbonate was chosen and converted into hydroxyapatite (HA); silicon was then substituted into the HA. Then, the Si-HA was mixed with β-tricalcium phosphate (TCP) in the ratios 100:0 (S100T0), 70:30 (S70T30), 60:40 (S60T40), and 50:50 (S50T50). The materials were implanted for four and eight weeks in a rat calvarial bone defect model (8 mm). The MBCPTM (HA:β-TCP = 60:40, Biomatalante, Vigneux de Bretagne, France) was used as a control. After euthanasia, the bone tissue was analyzed by making histological slides. From the results, S60T40 showed the fastest bone regeneration in four weeks (p < 0.05). In addition, S60T40, S50T50, and MBCPTM showed significant new bone formation in eight weeks (p < 0.05). In conclusion, Si-HA/TCP showed potential as a bone graft material.

摘要

骨移植材料的需求一直在增加。在各种骨移植材料来源中，选择了碳酸钙含量高达99%的天然珊瑚并将其转化为羟基磷灰石（HA）；然后将硅取代到HA中。接着，将硅-羟基磷灰石（Si-HA）与β-磷酸三钙（TCP）按100:0（S100T0）、70:30（S70T30）、60:40（S60T40）和50:50（S50T50）的比例混合。将这些材料植入大鼠颅骨骨缺损模型（8毫米）中4周和8周。使用MBCPTM（HA:β-TCP = 60:40，Biomatalante，法国布列塔尼维格涅）作为对照。安乐死后，通过制作组织学切片对骨组织进行分析。结果显示，S60T40在4周时骨再生最快（p < 0.05）。此外，S60T40、S50T50和MBCPTM在8周时显示出显著的新骨形成（p < 0.05）。总之，Si-HA/TCP作为骨移植材料具有潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57d6/5456508/bd4746baf9a9/materials-09-00097-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57d6/5456508/1fd9e9e2b55d/materials-09-00097-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57d6/5456508/0b9c64f21bdc/materials-09-00097-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57d6/5456508/47d04d79b2e0/materials-09-00097-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57d6/5456508/bd4746baf9a9/materials-09-00097-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57d6/5456508/1fd9e9e2b55d/materials-09-00097-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57d6/5456508/0b9c64f21bdc/materials-09-00097-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57d6/5456508/47d04d79b2e0/materials-09-00097-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57d6/5456508/bd4746baf9a9/materials-09-00097-g004.jpg

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本文引用的文献

1
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J Adv Prosthodont. 2014 Dec;6(6):528-38. doi: 10.4047/jap.2014.6.6.528. Epub 2014 Dec 17.
2
Human embryonic stem cells and macroporous calcium phosphate construct for bone regeneration in cranial defects in rats.人胚胎干细胞与大孔磷酸钙支架用于大鼠颅骨缺损的骨再生
Acta Biomater. 2014 Oct;10(10):4484-93. doi: 10.1016/j.actbio.2014.06.027. Epub 2014 Jun 24.
3
Bone regeneration via novel macroporous CPC scaffolds in critical-sized cranial defects in rats.
通过新型大孔磷酸钙骨水泥支架促进大鼠临界尺寸颅骨缺损的骨再生。
Dent Mater. 2014 Jul;30(7):e199-207. doi: 10.1016/j.dental.2014.03.008. Epub 2014 Apr 24.
4
A comparative evaluation of the systemic and local alendronate treatment in synthetic bone graft: a histologic and histomorphometric study in a rat calvarial defect model.合成骨移植物中阿仑膦酸钠全身和局部治疗的比较评价：大鼠颅骨缺损模型中的组织学和组织形态计量学研究。
Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Nov;114(5 Suppl):S146-52. doi: 10.1016/j.oooo.2011.09.027. Epub 2012 May 11.
5
Resolution of surgically created three-wall intrabony defects in implants using three different biomaterials: an in vivo study.三种不同生物材料在种植体三壁骨内缺损愈合中的应用：一项体内研究
Clin Oral Implants Res. 2011 Mar;22(3):343-8. doi: 10.1111/j.1600-0501.2010.01978.x. Epub 2010 Sep 10.
6
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Biomaterials. 2010 Mar;31(7):1465-85. doi: 10.1016/j.biomaterials.2009.11.050. Epub 2009 Dec 7.
7
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8
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9
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J Mater Sci Mater Med. 2007 Feb;18(2):225-35. doi: 10.1007/s10856-006-0684-7.
10
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J Periodontol. 2006 Jan;77(1):39-45. doi: 10.1902/jop.2006.77.1.39.