Ewig S, Bierhoff E, Luster W, Steudel A, Niese D
Medizinische Klinik der Universität Bonn.
Klin Wochenschr. 1991 Jul 22;69(10):449-53. doi: 10.1007/BF01666835.
We describe a case of an HIV-infected intravenous drug-abuser who died of progressive cytomegalovirus encephalitis despite successful treatment of cytomegalovirus retinitis with ganciclovir. On autopsy, complete remission of retinitis and widespread cytomegalovirus-encephalitis could be demonstrated. Therapeutic failure therefore seems attributable to insufficient CNS-distribution of ganciclovir rather than to ganciclovir-resistant cytomegalovirus strains.
我们描述了一例感染人类免疫缺陷病毒（HIV）的静脉注射吸毒者，尽管用更昔洛韦成功治疗了巨细胞病毒性视网膜炎，但仍死于进行性巨细胞病毒性脑炎。尸检时，可证实视网膜炎完全缓解且存在广泛的巨细胞病毒性脑炎。因此，治疗失败似乎归因于更昔洛韦在中枢神经系统的分布不足，而非更昔洛韦耐药的巨细胞病毒株。
