Zaki Magdy E A, Soliman Hanan A, Hiekal Ola A, Rashad Aymn E
Photochemistry Department, National Research Centre, Dokki, Cairo, Egypt.
Z Naturforsch C J Biosci. 2006 Jan-Feb;61(1-2):1-5. doi: 10.1515/znc-2006-1-201.
Pyrazolopyranopyrimidines 6a-c and 8a-c were prepared from the reaction of compounds 4a-c or 7a-c with methylamine or ammonium hydroxide solutions. Treatment of compounds 6a-c or 8a-c with 2-chloroethyl methyl ether afforded their corresponding acyclonucleosides 9a-c or 10a-c, respectively, as a new class of acyclonucleosides. All prepared compounds were tested as anti-inflammatory agents and some of them revealed moderate to potent anti-inflammatory activity.
吡唑并吡喃嘧啶6a - c和8a - c是由化合物4a - c或7a - c与甲胺或氢氧化铵溶液反应制备而成。用2 - 氯乙基甲基醚处理化合物6a - c或8a - c，分别得到它们相应的无环核苷9a - c或10a - c，作为一类新型的无环核苷。所有制备的化合物都作为抗炎剂进行了测试，其中一些显示出中度至强效的抗炎活性。
