高胆固醇血症和胆结石的自我报告病史与前列腺癌风险

Self-reported history of hypercholesterolaemia and gallstones and the risk of prostate cancer.

作者信息

Bravi F, Scotti L, Bosetti C, Talamini R, Negri E, Montella M, Franceschi S, La Vecchia C

机构信息

Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.

出版信息

Ann Oncol. 2006 Jun;17(6):1014-7. doi: 10.1093/annonc/mdl080. Epub 2006 Apr 12.

DOI:10.1093/annonc/mdl080

PMID:16611646

Abstract

BACKGROUND

Although prostate cancer is one of the most common male cancers, its aetiology-and particularly the role of comorbidity-remains poorly understood.

PATIENTS AND METHODS

Between 1991 and 2002, a case-control study on prostate cancer was conducted in Italy. This included 1294 men under the age of 75 years with incident, histologically confirmed prostate cancer, and 1451 controls, admitted to the same hospitals as cases for a wide spectrum of acute, non-neoplastic diseases. The subjects' self-reported history of selected medical conditions was assessed through a structured and satisfactorily reproducible questionnaire. Multivariate odds ratios (ORs) and 95% confidence intervals (CIs) were obtained after allowance for major potential confounding factors.

RESULTS

A significant direct relation was observed between hypercholesterolaemia and prostate cancer (OR = 1.51, 95% CI 1.23-1.85). This association was stronger (OR = 1.80) in older subjects (age > or =65) than in younger ones (OR = 1.32). A non-significant excess risk of prostate cancer was also observed for gallstones (OR = 1.26, 95% CI 0.93-1.70) and the relation was apparently stronger in patients with lower body mass index (OR = 1.59).

CONCLUSIONS

This study suggests a possible relation between hypercholesterolaemia and prostate cancer.

摘要

背景

尽管前列腺癌是最常见的男性癌症之一，但其病因——尤其是合并症的作用——仍知之甚少。

患者与方法

1991年至2002年间，在意大利进行了一项前列腺癌病例对照研究。该研究纳入了1294名75岁以下新诊断的、经组织学确诊的前列腺癌男性患者，以及1451名对照者，这些对照者因各种急性非肿瘤性疾病与病例患者入住同一家医院。通过一份结构化且重复性良好的问卷评估受试者自我报告的特定疾病史。在考虑主要潜在混杂因素后，获得多变量比值比（OR）和95%置信区间（CI）。

结果

观察到高胆固醇血症与前列腺癌之间存在显著的直接关联（OR = 1.51，95% CI 1.23 - 1.85）。这种关联在老年受试者（年龄≥65岁）中更强（OR = 1.80），而在年轻受试者中较弱（OR = 1.32）。胆结石患者患前列腺癌的风险也有非显著性增加（OR = 1.26，95% CI 0.93 - 1.70），且这种关联在体重指数较低的患者中似乎更强（OR = 1.59）。