Dipartimento di Epidemiologia, Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy.
Ann Epidemiol. 2011 Nov;21(11):835-41. doi: 10.1016/j.annepidem.2011.07.007.
To provide information on the role of the metabolic syndrome on prostate cancer risk.
We examined data from a multicentric Italian case-control study. Cases were 1294 patients with incident, histologically confirmed prostate cancer. Controls were 1451 men hospitalized with acute, non-neoplastic conditions. All subjects were younger than 75 years. The metabolic syndrome was defined according to selected indicators of abdominal obesity, hypercholesterolemia, hypertension, and diabetes. We computed multivariate odds ratios (OR) and 95% confidence intervals (CI) using unconditional logistic regression.
Considering separate components of the metabolic syndrome, the ORs were 0.98 (95% CI, 0.72-1.34) for diabetes, 1.14 (95% CI, 0.96-1.36) for hypertension, 1.54 (95% CI, 1.26-1.89) for hypercholesterolemia, and 1.02 (95% CI, 0.86-1.21) for abdominal obesity. The OR of prostate cancer was 1.66 (95% CI, 1.22-2.28) in men with metabolic syndrome compared with those without. We found ORs of 1.02 (95% CI, 0.83-1.26) for men with one component of the metabolic syndrome, 1.12 (95% CI, 0.89-1.42) for two, 1.65 (95% CI, 1.15-2.36) for three, and 3.99 (95% CI, 1.03-15.4) for four compared with no components.
The metabolic syndrome was associated with the risk of prostate cancer in this population.
提供代谢综合征对前列腺癌风险影响的相关信息。
我们研究了一项多中心意大利病例对照研究的数据。病例组为 1294 名患有组织学确诊的前列腺癌的新发患者。对照组为 1451 名因急性非肿瘤疾病住院的男性。所有研究对象年龄均小于 75 岁。代谢综合征根据腹部肥胖、高胆固醇血症、高血压和糖尿病等特定指标进行定义。我们采用非条件逻辑回归计算了多变量比值比（OR）及其 95%置信区间（CI）。
考虑到代谢综合征的单独组成部分，糖尿病的 OR 值为 0.98（95%CI，0.72-1.34），高血压为 1.14（95%CI，0.96-1.36），高胆固醇血症为 1.54（95%CI，1.26-1.89），腹部肥胖为 1.02（95%CI，0.86-1.21）。与无代谢综合征的男性相比，患有代谢综合征的男性患前列腺癌的 OR 值为 1.66（95%CI，1.22-2.28）。我们发现，患有代谢综合征一个组成部分的男性 OR 值为 1.02（95%CI，0.83-1.26），两个组成部分为 1.12（95%CI，0.89-1.42），三个组成部分为 1.65（95%CI，1.15-2.36），四个组成部分为 3.99（95%CI，1.03-15.4）。
在该人群中，代谢综合征与前列腺癌风险相关。
