Chen G X, Shu C D, He J
324 Hospital, Chongqing, China.
Biomater Artif Cells Immobilization Biotechnol. 1991;19(1):277-81. doi: 10.3109/10731199109117833.
After one hour cross-linked agarose encapsulated activated charcoal hemoperfusion, there was slight increase of total white cells and neutrophil count, but the neutrophil adherence was 16.87 +/- 5.26% and marked lower than that before hemoperfusion (59.91 +/- 5.26%, p less than 0.05). Using glassball hemoperfusion as control, the neutrophil adherence also decreased but not so obvious as the former. Adherence is a cell property that may affect granulocyte margination, diapedesis, chemotaxis and phagocytic function, so the above investigations showed that both the hemoperfusion process and the charcoal itself may reduce the host defence mechanism. There were no change of the peroxidase and alkaline phosphatase activities of neutrophils during one hour cross-linked agarose encapsulated activated charcoal hemoperfusion.
经过一小时的交联琼脂糖包裹活性炭血液灌流后，白细胞总数和中性粒细胞计数略有增加，但中性粒细胞黏附率为16.87±5.26%，明显低于血液灌流前（59.91±5.26%，p<0.05）。以玻璃珠血液灌流作为对照，中性粒细胞黏附率也有所下降，但不如前者明显。黏附是一种可能影响粒细胞靠边、渗出、趋化性和吞噬功能的细胞特性，因此上述研究表明，血液灌流过程和活性炭本身都可能降低宿主防御机制。在一小时的交联琼脂糖包裹活性炭血液灌流过程中，中性粒细胞的过氧化物酶和碱性磷酸酶活性没有变化。
