Auldridge Michele E, McCarty Donald R, Klee Harry J
Howard Hughes Medical Institute, The Jack H Skirball Center for Chemical Biology and Proteomics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.
Curr Opin Plant Biol. 2006 Jun;9(3):315-21. doi: 10.1016/j.pbi.2006.03.005. Epub 2006 Apr 17.
The oxidative cleavage of carotenoids leads to the production of apocarotenoids and is catalyzed by a family of carotenoid cleavage dioxygenases (CCDs). CCDs often exhibit substrate promiscuity, which probably contributes to the diversity of apocarotenoids found in nature. Biologically and commercially important apocarotenoids include the phytohormone abscisic acid, the visual and signaling molecules retinal and retinoic acid, and the aromatic volatile beta-ionone. Unexpected properties associated with the CCD catalytic products emphasize their role in many aspects of plant growth and development. For instance, CCD7 and CCD8 produce a novel, graft-transmissible hormone that controls axillary shoot growth in plants. Here, CCDs are discussed according to their roles in the biosynthesis of these products. Recent studies regarding their mechanism of action are also addressed.
类胡萝卜素的氧化裂解会产生脱辅基类胡萝卜素，该过程由一类类胡萝卜素裂解双加氧酶（CCD）催化。CCD通常表现出底物混杂性，这可能导致了自然界中脱辅基类胡萝卜素的多样性。具有生物学和商业重要性的脱辅基类胡萝卜素包括植物激素脱落酸、视觉和信号分子视黄醛和视黄酸，以及芳香挥发性物质β-紫罗兰酮。与CCD催化产物相关的意外特性突显了它们在植物生长和发育的许多方面所起的作用。例如，CCD7和CCD8会产生一种新型的、可通过嫁接传递的激素，该激素控制植物腋芽的生长。在此，将根据CCD在这些产物生物合成中的作用进行讨论。同时也会探讨有关其作用机制的最新研究。
