Zammit David J, Turner Damian L, Klonowski Kimberly D, Lefrançois Leo, Cauley Linda S
Department of Immunology, University of Connecticut Health Center, Farmington, 06032, USA.
Immunity. 2006 Apr;24(4):439-49. doi: 10.1016/j.immuni.2006.01.015.
Activated virus-specific CD8 T cells remain in the lung airways for several months after influenza virus infection. We show that maintenance of this cell population is dependent upon the route of infection and prolonged presentation of viral antigen in the draining lymph nodes (DLN) of the respiratory tract. The local effects on T cell migration have been examined. We show retention of virus-specific CD8 T cells in the mediastinal lymph node (MLN) and continuing recruitment of blood-borne migrants into the lung airways during antigen presentation. These data show that antigen that is retained after pulmonary influenza virus infection controls the migratory pattern and activation state of virus-specific CD8 T cells near the site of virus amplification.
流感病毒感染后，活化的病毒特异性CD8 T细胞会在肺气道中持续存在数月。我们发现，这群细胞的维持依赖于感染途径以及呼吸道引流淋巴结（DLN）中病毒抗原的持续呈递。我们已经研究了对T细胞迁移的局部影响。我们发现，在抗原呈递期间，病毒特异性CD8 T细胞会滞留在纵隔淋巴结（MLN）中，并且血源性迁移细胞会持续招募到肺气道中。这些数据表明，肺部流感病毒感染后留存的抗原控制着病毒扩增部位附近病毒特异性CD8 T细胞的迁移模式和活化状态。
