Brébion Gildas, David Anthony S, Bressan Rodrigo A, Pilowsky Lyn S
Institute of Psychiatry, London, UK.
J Clin Exp Neuropsychol. 2006 Apr;28(3):370-82. doi: 10.1080/13803390590935390.
The role of slowing of processing speed in verbal memory impairment in patients with schizophrenia was investigated. Forty-one patients with schizophrenia and 41 healthy control subjects were administered a verbal memory task involving free recall of three lists of words, which varied in their degree of semantic organization. Standard processing speed tests were administered as well. Regression analyses were conducted on the number of words recalled in each list. A global processing speed measure was a significant predictor of the recall of each list in patients. Patients were very significantly impaired in the recall of the three lists relative to healthy controls. However, when the processing speed measure was entered in the regression, the significance of diagnosis was considerably reduced for one of the lists, with no semantic organization, and eliminated for the other two lists which contained semantic organization. These findings suggest that slowing in processing speed is an important contributor to verbal memory impairment in patients with schizophrenia. The possible role of various specific slowing functions is discussed.
研究了处理速度减慢在精神分裂症患者言语记忆损害中的作用。对41名精神分裂症患者和41名健康对照者进行了一项言语记忆任务，该任务涉及自由回忆三个单词列表，这些列表在语义组织程度上有所不同。同时还进行了标准的处理速度测试。对每个列表中回忆出的单词数量进行了回归分析。整体处理速度指标是患者每个列表回忆情况的显著预测因子。与健康对照者相比，患者在三个列表的回忆方面存在非常显著的损害。然而，当将处理速度指标纳入回归分析时，对于其中一个没有语义组织的列表，诊断的显著性大幅降低，而对于另外两个包含语义组织的列表，诊断的显著性则完全消除。这些发现表明，处理速度减慢是精神分裂症患者言语记忆损害的一个重要因素。文中还讨论了各种特定减慢功能的可能作用。
