在感染两种含有完整SV40基因组的腺病毒2-SV40杂种病毒期间，猴病毒40的DNA复制、转录和抗原诱导。
Simian virus 40 DNA replication, transcription, and antigen induction during infection with two adenovirus 2-SV40 hybrids that contain the entire SV40 genome.
作者信息
Siegel S E, Patch C T, Lewis A M, Levine A S
出版信息
J Virol. 1975 Jul;16(1):43-52. doi: 10.1128/JVI.16.1.43-52.1975.
Abstract
The Ad2++hey hybrid virus population produces simian virus 40 (SV40) efficiently during lytic infection, whereas Ad2++ley does not, although both hybrids contain a complete SV40 genome. In this report, we demonstrate the synthesis of nonhydrid SV40 DNA in Ad2++HEY-infected Vero cells, but only early SV40 RNA is transcribed efficiently in Ad2++LEY-infected cells. Ad2++HEY induces SV40 U, T, and V antigens during lytic infection of African green monkey kidney cells, whereas Ad2++LEY induces only SV40 U and T antigens. These variations in the behavior of Ad2++HEY and Ad2++LEY regarding expression of SV40 functions probably reflect differences in the rate of SV40 excision from the hybrid genomes.
摘要
Ad2++hey 杂交病毒群体在裂解感染期间能高效产生猿猴病毒 40（SV40），而 Ad2++ley 则不能，尽管这两种杂交病毒都含有完整的 SV40 基因组。在本报告中，我们证明了在 Ad2++HEY 感染的 Vero 细胞中合成了非杂交的 SV40 DNA，但在 Ad2++LEY 感染的细胞中只有早期 SV40 RNA 能有效转录。Ad2++HEY 在非洲绿猴肾细胞的裂解感染过程中诱导 SV40 U、T 和 V 抗原，而 Ad2++LEY 仅诱导 SV40 U 和 T 抗原。Ad2++HEY 和 Ad2++LEY 在 SV40 功能表达方面行为的这些差异可能反映了从杂交基因组中切除 SV40 的速率差异。
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