Capestany Cindy A, Kuboniwa Masae, Jung Il-Young, Park Yoonsuk, Tribble Gena D, Lamont Richard J
Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610-0424, USA.
Infect Immun. 2006 May;74(5):3002-5. doi: 10.1128/IAI.74.5.3002-3005.2006.
The oral pathogen Porphyromonas gingivalis expresses a homolog of the internalin family protein InlJ. Inactivation of inlJ reduced monospecies biofilm formation by P. gingivalis. In contrast, heterotypic P. gingivalis-Streptococcus gordonii biofilm formation was enhanced in the InlJ-deficient mutant. The results indicate a nuanced role for InlJ in regulating biofilm accumulations of P. gingivalis.
口腔病原体牙龈卟啉单胞菌表达内化素家族蛋白InlJ的同源物。inlJ的失活减少了牙龈卟啉单胞菌的单菌种生物膜形成。相比之下,在InlJ缺陷型突变体中,牙龈卟啉单胞菌与戈登链球菌的异型生物膜形成增强。结果表明InlJ在调节牙龈卟啉单胞菌生物膜积聚中具有微妙的作用。