Bgp是伯氏疏螺旋体N40菌株分泌的一种糖胺聚糖结合蛋白，具有核苷酶活性，对免疫缺陷小鼠的感染并非必需。
Bgp, a secreted glycosaminoglycan-binding protein of Borrelia burgdorferi strain N40, displays nucleosidase activity and is not essential for infection of immunodeficient mice.
作者信息
Parveen Nikhat, Cornell Kenneth A, Bono James L, Chamberland Christen, Rosa Patricia, Leong John M
机构信息
Department of Microbiology and Molecular Genetics, ICPH Building, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103-2714, USA.
出版信息
Infect Immun. 2006 May;74(5):3016-20. doi: 10.1128/IAI.74.5.3016-3020.2006.
Abstract
Bgp, one of the surface-localized glycosaminoglycan-binding proteins of the Lyme disease spirochete, Borrelia burgdorferi, exhibited nucleosidase activity. Infection of SCID mice with B. burgdorferi strain N40 mutants harboring a targeted insertion in bgp and apparently retaining all endogenous plasmids revealed that Bgp is not essential for colonization of immunocompromised mice.
摘要
Bgp是莱姆病螺旋体伯氏疏螺旋体表面定位的糖胺聚糖结合蛋白之一，表现出核苷酶活性。用携带靶向插入bgp且显然保留所有内源性质粒的伯氏疏螺旋体N40突变株感染SCID小鼠，结果显示Bgp对于免疫受损小鼠的定殖并非必需。
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2
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Nat Rev Microbiol. 2005 Feb;3(2):129-43. doi: 10.1038/nrmicro1086.
3
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Plasmid. 2005 Jan;53(1):1-13. doi: 10.1016/j.plasmid.2004.10.006. Epub 2004 Dec 16.
4
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Parasitol Today. 1989 Oct;5(10):330-3. doi: 10.1016/0169-4758(89)90128-2.
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