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给肺部注射抗体可保护小鼠免受肺鼠疫感染。

Administration of antibody to the lung protects mice against pneumonic plague.

作者信息

Hill Jim, Eyles Jim E, Elvin Stephen J, Healey Gareth D, Lukaszewski Roman A, Titball Richard W

机构信息

Defence Science and Technology Laboratory, Porton Down, Wiltshire SP4 OJQ, United Kingdom.

出版信息

Infect Immun. 2006 May;74(5):3068-70. doi: 10.1128/IAI.74.5.3068-3070.2006.

DOI:10.1128/IAI.74.5.3068-3070.2006
PMID:16622253
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1459704/
Abstract

Intratracheal delivery of aerosolized monoclonal antibodies with specificity for Yersinia pestis LcrV and F1 antigens protected mice in a model of pneumonic plague. These data support the utility of inhaled antibodies as a fast-acting postexposure treatment for plague.

摘要

经气管递送对鼠疫耶尔森菌LcrV和F1抗原具有特异性的雾化单克隆抗体，可在肺鼠疫模型中保护小鼠。这些数据支持吸入性抗体作为鼠疫暴露后快速起效治疗方法的实用性。

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本文引用的文献

1
Non-invasive pulmonary aerosol delivery in mice by the endotracheal route.通过气管内途径对小鼠进行非侵入性肺气溶胶给药。
Eur J Pharm Biopharm. 2005 Oct;61(3):214-8. doi: 10.1016/j.ejpb.2005.04.009. Epub 2005 Jul 20.
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Yersinia pestis (plague) vaccines.鼠疫耶尔森菌（鼠疫）疫苗。
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Synergistic protection of mice against plague with monoclonal antibodies specific for the F1 and V antigens of Yersinia pestis.用针对鼠疫耶尔森氏菌F1和V抗原的单克隆抗体对小鼠进行鼠疫协同保护。
Infect Immun. 2003 Apr;71(4):2234-8. doi: 10.1128/IAI.71.4.2234-2238.2003.
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Antimicrobial postexposure prophylaxis for anthrax: adverse events and adherence.炭疽病的抗菌暴露后预防：不良事件与依从性
Emerg Infect Dis. 2002 Oct;8(10):1124-32. doi: 10.3201/eid0810.020349.
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Br Med Bull. 2002;62:163-73. doi: 10.1093/bmb/62.1.163.
6
Passive antibody administration (immediate immunity) as a specific defense against biological weapons.被动抗体给药（即时免疫）作为针对生物武器的一种特异性防御手段。
Emerg Infect Dis. 2002 Aug;8(8):833-41. doi: 10.3201/eid0808.010516.
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Treating systemic diseases via the lung.通过肺部治疗全身性疾病。
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10
Transferable plasmid-mediated resistance to streptomycin in a clinical isolate of Yersinia pestis.鼠疫耶尔森氏菌临床分离株中可转移的质粒介导的链霉素抗性
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