• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Synergistic protection of mice against plague with monoclonal antibodies specific for the F1 and V antigens of Yersinia pestis.用针对鼠疫耶尔森氏菌F1和V抗原的单克隆抗体对小鼠进行鼠疫协同保护。
Infect Immun. 2003 Apr;71(4):2234-8. doi: 10.1128/IAI.71.4.2234-2238.2003.
2
Administration of antibody to the lung protects mice against pneumonic plague.给肺部注射抗体可保护小鼠免受肺鼠疫感染。
Infect Immun. 2006 May;74(5):3068-70. doi: 10.1128/IAI.74.5.3068-3070.2006.
3
Adenovirus-mediated delivery of an anti-V antigen monoclonal antibody protects mice against a lethal Yersinia pestis challenge.腺病毒介导的抗V抗原单克隆抗体递送可保护小鼠免受致死性鼠疫耶尔森菌攻击。
Infect Immun. 2009 Apr;77(4):1561-8. doi: 10.1128/IAI.00856-08. Epub 2009 Jan 5.
4
Evaluation of human antibodies from vaccinated volunteers for protection against infection.评估接种疫苗的志愿者体内的人抗体，以预防感染。
Microbiol Spectr. 2024 Oct 3;12(10):e0105424. doi: 10.1128/spectrum.01054-24. Epub 2024 Aug 27.
5
Concomitant administration of Yersinia pestis specific monoclonal antibodies with plague vaccine has a detrimental effect on vaccine mediated immunity.鼠疫耶尔森菌特异性单克隆抗体与鼠疫疫苗同时使用会对疫苗介导的免疫产生有害影响。
Vaccine. 2007 Oct 16;25(42):7301-6. doi: 10.1016/j.vaccine.2007.08.021. Epub 2007 Aug 31.
6
Recombinant V antigen protects mice against pneumonic and bubonic plague caused by F1-capsule-positive and -negative strains of Yersinia pestis.重组V抗原可保护小鼠免受由鼠疫耶尔森氏菌F1荚膜阳性和阴性菌株引起的肺鼠疫和腺鼠疫。
Infect Immun. 1996 Nov;64(11):4580-5. doi: 10.1128/iai.64.11.4580-4585.1996.
7
Protection of mice from fatal bubonic and pneumonic plague by passive immunization with monoclonal antibodies against the F1 protein of Yersinia pestis.通过用抗鼠疫耶尔森菌F1蛋白的单克隆抗体进行被动免疫来保护小鼠免受致命性腺鼠疫和肺鼠疫的侵害。
Am J Trop Med Hyg. 1997 Apr;56(4):471-3. doi: 10.4269/ajtmh.1997.56.471.
8
Kinetics of the immune response to the (F1+V) vaccine in models of bubonic and pneumonic plague.在腺鼠疫和肺鼠疫模型中对（F1+V）疫苗免疫反应的动力学
Vaccine. 2007 Jan 22;25(6):1142-8. doi: 10.1016/j.vaccine.2006.09.052. Epub 2006 Oct 2.
9
TNFα and IFNγ contribute to F1/LcrV-targeted immune defense in mouse models of fully virulent pneumonic plague.TNFα 和 IFNγ 有助于完全毒力肺鼠疫小鼠模型中针对 F1/LcrV 的免疫防御。
Vaccine. 2010 Dec 16;29(2):357-62. doi: 10.1016/j.vaccine.2010.08.099. Epub 2010 Sep 15.
10
Humoral and cellular immune correlates of protection against bubonic plague by a live Yersinia pseudotuberculosis vaccine.体液和细胞免疫相关性保护免受鼠疫耶尔森菌活疫苗引起的腺鼠疫。
Vaccine. 2019 Jan 3;37(1):123-129. doi: 10.1016/j.vaccine.2018.11.022. Epub 2018 Nov 19.

引用本文的文献

1
Evaluation of human antibodies from vaccinated volunteers for protection against infection.评估接种疫苗的志愿者体内的人抗体，以预防感染。
Microbiol Spectr. 2024 Oct 3;12(10):e0105424. doi: 10.1128/spectrum.01054-24. Epub 2024 Aug 27.
2
Towards a Yersinia pestis lipid A recreated in an Escherichia coli scaffold genome.在大肠杆菌支架基因组中重建鼠疫耶尔森菌脂多糖A。
Access Microbiol. 2024 Jul 17;6(7). doi: 10.1099/acmi.0.000723.v3. eCollection 2024.
3
Characterization of two affinity matured Anti-Yersinia pestis F1 human antibodies with medical countermeasure potential.两种具有医学应对潜力的亲和成熟抗鼠疫耶尔森氏菌 F1 人抗体的特性。
PLoS One. 2024 Jul 2;19(7):e0305034. doi: 10.1371/journal.pone.0305034. eCollection 2024.
4
Functional assays to screen and select monoclonal antibodies that target .筛选和选择针对. 的单克隆抗体的功能测定法。
Hum Vaccin Immunother. 2023 Aug 1;19(2):2216085. doi: 10.1080/21645515.2023.2216085. Epub 2023 Jun 8.
5
Polyclonal Antibodies Derived from Transchromosomic Bovines Vaccinated with the Recombinant F1-V Vaccine Increase Bacterial Opsonization In Vitro and Protect Mice from Pneumonic Plague.用重组F1-V疫苗接种的转染色体牛产生的多克隆抗体可增强体外细菌调理作用，并保护小鼠免受肺鼠疫感染。
Antibodies (Basel). 2023 May 8;12(2):33. doi: 10.3390/antib12020033.
6
Direct and indirect impacts of synthetic biology on biodiversity conservation.合成生物学对生物多样性保护的直接和间接影响。
iScience. 2022 Oct 20;25(11):105423. doi: 10.1016/j.isci.2022.105423. eCollection 2022 Nov 18.
7
Layered and integrated medical countermeasures against infections in C57BL/6 mice.针对C57BL/6小鼠感染的分层与综合医学对策。
Front Microbiol. 2022 Aug 17;13:965572. doi: 10.3389/fmicb.2022.965572. eCollection 2022.
8
Potential human immunotherapeutics for plague.鼠疫的潜在人类免疫疗法。
Immunother Adv. 2021 Oct 5;1(1):ltab020. doi: 10.1093/immadv/ltab020. eCollection 2021 Jan.
9
Development of a dual antigen lateral flow immunoassay for detecting Yersinia pestis.双抗原侧向流动免疫分析法的建立及其用于鼠疫耶尔森氏菌的检测。
PLoS Negl Trop Dis. 2022 Mar 23;16(3):e0010287. doi: 10.1371/journal.pntd.0010287. eCollection 2022 Mar.
10
Plague Prevention and Therapy: Perspectives on Current and Future Strategies.鼠疫的预防与治疗：当前及未来策略展望
Biomedicines. 2021 Oct 9;9(10):1421. doi: 10.3390/biomedicines9101421.

本文引用的文献

1
Generation and characterization of a protective monoclonal antibody to Pseudomonas aeruginosa PcrV.铜绿假单胞菌PcrV保护性单克隆抗体的产生与鉴定
J Infect Dis. 2002 Jul 1;186(1):64-73. doi: 10.1086/341069. Epub 2002 Jun 14.
2
Anti-V antigen antibody protects macrophages from Yersinia pestis -induced cell death and promotes phagocytosis.抗V抗原抗体可保护巨噬细胞免受鼠疫耶尔森菌诱导的细胞死亡，并促进吞噬作用。
Microb Pathog. 2002 May;32(5):227-37. doi: 10.1006/mpat.2002.0498.
3
Role of fraction 1 antigen of Yersinia pestis in inhibition of phagocytosis.鼠疫耶尔森菌1号抗原在抑制吞噬作用中的作用。
Infect Immun. 2002 Mar;70(3):1453-60. doi: 10.1128/IAI.70.3.1453-1460.2002.
4
Yersinia enterocolitica evasion of the host innate immune response by V antigen-induced IL-10 production of macrophages is abrogated in IL-10-deficient mice.小肠结肠炎耶尔森菌通过V抗原诱导巨噬细胞产生白细胞介素-10来逃避宿主天然免疫反应的机制，在白细胞介素-10缺陷型小鼠中被消除。
J Immunol. 2002 Feb 1;168(3):1315-21. doi: 10.4049/jimmunol.168.3.1315.
5
Therapeutic administration of anti-PcrV F(ab')(2) in sepsis associated with Pseudomonas aeruginosa.抗绿脓杆菌外毒素V F(ab')(2)在铜绿假单胞菌相关性脓毒症中的治疗应用。
J Immunol. 2001 Nov 15;167(10):5880-6. doi: 10.4049/jimmunol.167.10.5880.
6
Plague vaccine research and development.
J Appl Microbiol. 2001 Oct;91(4):606-8. doi: 10.1046/j.1365-2672.2001.01497.x.
7
[Resurgence of the plague in the Ikongo district of Madagascar in 1998. 2. Reservoirs and vectors implicated].[1998年马达加斯加伊孔戈区鼠疫的再度流行。2. 涉及的储存宿主和病媒]
Bull Soc Pathol Exot. 2001 May;94(2):119-22.
8
[Resurgence of the plague in the Ikongo district of Madagascar in 1998. 1. Epidemiological aspects in the human population].[1998年马达加斯加伊孔戈区鼠疫的再次流行。1. 人群中的流行病学情况]
Bull Soc Pathol Exot. 2001 May;94(2):115-8.
9
Transferable plasmid-mediated resistance to streptomycin in a clinical isolate of Yersinia pestis.鼠疫耶尔森氏菌临床分离株中可转移的质粒介导的链霉素抗性
Emerg Infect Dis. 2001 Jan-Feb;7(1):43-8. doi: 10.3201/eid0701.010106.
10
A single dose sub-unit vaccine protects against pneumonic plague.单剂量亚单位疫苗可预防肺鼠疫。
Vaccine. 2000 Oct 15;19(4-5):566-71. doi: 10.1016/s0264-410x(00)00159-6.

用针对鼠疫耶尔森氏菌F1和V抗原的单克隆抗体对小鼠进行鼠疫协同保护。

Synergistic protection of mice against plague with monoclonal antibodies specific for the F1 and V antigens of Yersinia pestis.

作者信息

Hill Jim, Copse Catherine, Leary Sophie, Stagg Anthony J, Williamson E Diane, Titball Richard W

机构信息

Defence Science and Technology Laboratory, Porton Down, Wiltshire SP4 OJQ, United Kingdom.

出版信息

Infect Immun. 2003 Apr;71(4):2234-8. doi: 10.1128/IAI.71.4.2234-2238.2003.

DOI:10.1128/IAI.71.4.2234-2238.2003
PMID:12654847
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC152045/
Abstract

Monoclonal antibodies specific for Yersinia pestis V antigen and F1 antigen, administered singly or in combination, protected mice in models of bubonic and pneumonic plague. Antibodies showed synergy when administered prophylactically and as a therapy 48 h postinfection. Monoclonal antibodies therefore have potential as a treatment for plague.

摘要

针对鼠疫耶尔森菌V抗原和F1抗原的单克隆抗体，单独或联合使用，可在腺鼠疫和肺鼠疫模型中保护小鼠。抗体在预防性给药以及感染后48小时作为治疗药物使用时表现出协同作用。因此，单克隆抗体有潜力用于鼠疫治疗。