Figard Hélène, Mougin Fabienne, Gaume Vincent, Berthelot Alain
UFR STAPS Besançon, 31 chemin de l'Epitaphe 25000 Besançon, Université de Franche-Comté, France.
J Bone Miner Metab. 2006;24(3):206-12. doi: 10.1007/s00774-005-0673-9.
Soybean proteins, a rich source of isoflavones, taken immediately after an ovariectomy prevent bone loss in rats. Exercise-induced stimuli are essential for bone growth. Few studies exist about the combined effects of swim training and soybean protein supplementation on bone metabolism. So, the purpose of this study was to investigate, in 48 female Sprague-Dawley rats (12 weeks old) the effects of an 8-week swim-training regimen (1 h/day, 5 days/week) and dietary soybean proteins (200 g/kg diet) on bone metabolism. Rats were randomly assigned to four groups: (1) ovariectomized fed with a semisynthetic control diet; (2) ovariectomized fed with a soybean protein-enriched semisynthetic diet; (3) ovariectomized trained to exercise and fed with control diet; (4) ovariectomized trained to exercise and fed with a soybean protein diet. Following the treatment period, body weight gain was identical in the four groups. Soybean protein supplementation increased bone calcium content, and reduced plasma osteocalcin values, without significant modification of calcium balance and net calcium absorption. Swim training enhanced plasma and bone calcium content and calcium balance and net calcium absorption. It did not modify either plasma osteocalcin values or urinary deoxypyridinoline excretion. Both exercise and soybean protein intake increased plasma on bone calcium without modifying net calcium absorption or bone markers. In conclusion, we demonstrated, in ovariectomized rats, that swimming exercise and dietary supplementation with soy proteins do not have synergistic effects on calcium metabolism and bone markers.
大豆蛋白富含异黄酮，在大鼠卵巢切除术后立即摄入可预防骨质流失。运动诱导的刺激对骨骼生长至关重要。关于游泳训练和补充大豆蛋白对骨代谢的联合作用的研究很少。因此，本研究的目的是在48只12周龄的雌性Sprague-Dawley大鼠中，研究8周游泳训练方案（每天1小时，每周5天）和膳食大豆蛋白（200克/千克饮食）对骨代谢的影响。大鼠被随机分为四组：（1）卵巢切除后喂食半合成对照饮食；（2）卵巢切除后喂食富含大豆蛋白的半合成饮食；（3）卵巢切除后训练运动并喂食对照饮食；（4）卵巢切除后训练运动并喂食大豆蛋白饮食。治疗期结束后，四组大鼠的体重增加相同。补充大豆蛋白可增加骨钙含量，降低血浆骨钙素值，而钙平衡和净钙吸收无明显改变。游泳训练可提高血浆和骨钙含量、钙平衡和净钙吸收。它对血浆骨钙素值或尿脱氧吡啶啉排泄均无影响。运动和摄入大豆蛋白均可增加血浆和骨钙含量，而不改变净钙吸收或骨标志物。总之，我们在卵巢切除的大鼠中证明，游泳运动和大豆蛋白膳食补充剂对钙代谢和骨标志物没有协同作用。
