水引发且金（I）催化的末端炔烃与邻炔基芳醛的串联加成/环化反应
Water-triggered and gold(I)-catalyzed cascade addition/cyclization of terminal alkynes with ortho-alkynylaryl aldehyde.
作者信息
Yao Xiaoquan, Li Chao-Jun
机构信息
Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 2K6, Canada.
出版信息
Org Lett. 2006 Apr 27;8(9):1953-5. doi: 10.1021/ol060645p.
PMID:16623593
Abstract
[reaction: see text] A highly efficient alkynylation-cyclization of terminal alkynes with ortho-alkynylaryl aldehydes leading to 1-alkynyl-1H-isochromenes was developed by using a gold-phosphine complex as catalyst in water. The reaction was dually promoted by an electron-donating phosphine ligand and water and was chelation-controlled.
摘要
[反应：见正文] 通过在水中使用金-膦配合物作为催化剂，开发了一种末端炔烃与邻炔基芳醛的高效炔基化-环化反应，生成1-炔基-1H-异苯并呋喃。该反应由供电子膦配体和水双重促进，且受螯合控制。
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