Kelly Michael G, Frizelle Frank A, Thornley Peter T, Beckert Lutz, Epton Michael, Lynch A Craig
Canterbury Respiratory Research Group, Department of Surgery, Christchurch Hospital, Private Bag 4710, Christchurch 8001, New Zealand.
Int J Colorectal Dis. 2006 Dec;21(8):754-7. doi: 10.1007/s00384-006-0094-9. Epub 2006 Apr 20.
One-third of patients with inflammatory bowel disease (IBD) has extracolonic manifestations. Inflammatory bowel-associated pulmonary disease is one of the less commonly recognized and more recently described manifestations. Here, we report the experience of our patients with inflammatory bowel-associated bronchiectasis.
A retrospective analysis of case notes of patients with IBD and respiratory manifestations was undertaken. Relevant demographic, clinical, radiological, and pulmonary physiology laboratory results were reviewed.
Ten patients with IBD and bronchiectasis were identified. Eight developed respiratory symptoms after surgery for IBD. Five of the ten had ulcerative colitis. Their lung function abnormality is mild to moderate in severity. Small airways disease (forced expiratory flow between 25-75% is <50%) was evident in seven of the ten patients.
This preliminary study supports an association between surgery for IBD and development of symptomatic lung disease, particularly bronchiectasis, in susceptible patients. The pulmonary manifestations of IBD in some patients may only become clinically significant after surgery and the withdrawal of medical treatment.
三分之一的炎症性肠病（IBD）患者有肠外表现。炎症性肠病相关的肺部疾病是较少被认识且最近才被描述的表现之一。在此，我们报告我们的炎症性肠病相关支气管扩张患者的情况。
对有IBD及呼吸系统表现的患者病历进行回顾性分析。回顾了相关的人口统计学、临床、放射学及肺生理学实验室结果。
确定了10例IBD合并支气管扩张患者。8例在IBD手术后出现呼吸道症状。10例中有5例患有溃疡性结肠炎。他们的肺功能异常程度为轻度至中度。10例患者中有7例存在小气道疾病（25%至75%用力呼气流量<50%）。
这项初步研究支持在IBD手术与易感患者出现有症状的肺部疾病（尤其是支气管扩张）之间存在关联。IBD在一些患者中的肺部表现可能仅在手术后及停止药物治疗后才具有临床意义。
