Dierkes-Globisch Alexandra, Mohr Hans
Department of Internal Medicine, Military Hospital of German Armed Forces Koblenz, Medical Division, Johannes-Gutenberg-University, Mainz, Germany
Eur J Intern Med. 2002 Sep;13(6):385. doi: 10.1016/s0953-6205(02)00097-3.
There is evidence that pulmonary function abnormalities are present in patients with inflammatory bowel disease (IBD). The aim of this crossover study was to assess the frequency of pulmonary dysfunction in patients with IBD and to define the importance of possible confounding factors. METHODS: We investigated a total of 44 patients with Crohn's disease or ulcerative colitis and no pulmonary symptoms or a history of respiratory diseases by means of pulmonary function testing and chest X-ray. As controls we examined 44 healthy subjects matched for gender, age, and smoking status. RESULTS: A total of 21% of the subjects with ulcerative colitis and 20% with Crohn's disease showed an obstructive and/or restrictive ventilatory defect. Pulmonary function abnormalities were significantly more frequent in patients with IBD than in the controls (5%, P<0.05). There was no correlation between pulmonary function abnormalities and site, activity, or duration of bowel disease, current medication, smoking habits, or history of atopy. CONCLUSIONS: Pulmonary involvement seems to be a more frequent extraintestinal manifestation of IBD than thus far supposed. The causes or confounding factors are uncertain.
有证据表明炎症性肠病（IBD）患者存在肺功能异常。这项交叉研究的目的是评估IBD患者肺功能障碍的发生率，并确定可能的混杂因素的重要性。方法：我们通过肺功能测试和胸部X线检查，对总共44例克罗恩病或溃疡性结肠炎患者进行了调查，这些患者无肺部症状或呼吸系统疾病史。作为对照，我们检查了44名性别、年龄和吸烟状况相匹配的健康受试者。结果：总共21%的溃疡性结肠炎患者和20%的克罗恩病患者表现出阻塞性和/或限制性通气缺陷。IBD患者的肺功能异常明显比对照组更常见（5%，P<0.05）。肺功能异常与肠道疾病的部位、活动度或病程、当前用药、吸烟习惯或特应性病史之间无相关性。结论：肺部受累似乎是IBD比迄今所认为的更常见的肠外表现。其原因或混杂因素尚不确定。
