Menezes V M, Soares B G O, Fontes C J F
Universidade Federal de Mato Grosso, Faculdade de Ciências Médicas, Av Fernando Correia da Costa S.N. Coxipó, Cuiabá MT, Brazil.
Cochrane Database Syst Rev. 2006 Apr 19;2006(2):CD004967. doi: 10.1002/14651858.CD004967.pub2.
Paracoccidioidomycosis is a fungal infection found in particular geographic localities in Latin America. Treatment can last for up to two years is often associated with complications, including relapse, but people may die without it.
To evaluate drugs used for treating paracoccidioidomycosis.
We searched the Cochrane Infectious Diseases Group Specialized Register (January 2006), CENTRAL (The Cochrane Library 2005, Issue 4), PubMed (1966 to January 2006), EMBASE (1974 to January 2006), LILACS (1982 to January 2006), conference proceedings, and reference lists. We also contacted researchers and pharmaceutical companies.
Randomized controlled trials comparing drugs for treating people with paracoccidioidomycosis.
Two authors independently assessed trial eligibility and methodological quality, and extracted data, including adverse events.
One trial with 42 participants met the inclusion criteria that compared imidazoles (itraconazole and ketoconazole) with sulfadiazine. No difference was detected for cure or clinical improvement, or serological titres after 10 months of treatment, and there was no difference detected in adverse events.
AUTHORS' CONCLUSIONS: The small number of participants and the short follow-up period impede definitive conclusions.
副球孢子菌病是一种真菌感染，在拉丁美洲的特定地理区域发现。治疗可能持续长达两年，且常伴有包括复发在内的并发症，但不进行治疗患者可能死亡。
评估用于治疗副球孢子菌病的药物。
我们检索了Cochrane传染病组专业注册库（2006年1月）、CENTRAL（Cochrane图书馆2005年第4期）、PubMed（1966年至2006年1月）、EMBASE（1974年至2006年1月）、LILACS（1982年至2006年1月）、会议论文集和参考文献列表。我们还联系了研究人员和制药公司。
比较治疗副球孢子菌病患者药物的随机对照试验。
两位作者独立评估试验的合格性和方法学质量，并提取数据，包括不良事件。
一项纳入42名参与者的试验符合纳入标准，该试验比较了咪唑类药物（伊曲康唑和酮康唑）与磺胺嘧啶。治疗10个月后，在治愈率、临床改善情况或血清学滴度方面未检测到差异，在不良事件方面也未检测到差异。
参与者数量少和随访期短妨碍得出确切结论。
