Coria Roberto, Kawasaki Laura, Torres-Quiroz Francisco, Ongay-Larios Laura, Sánchez-Paredes Edith, Velázquez-Zavala Nancy, Navarro-Olmos Rocio, Rodríguez-González Miriam, Aguilar-Corachán Rodrigo, Coello Gerardo
Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México, DF, Mexico.
FEMS Yeast Res. 2006 May;6(3):336-44. doi: 10.1111/j.1567-1364.2005.00022.x.
The mating pheromone response pathway in Saccharomyces cerevisiae is one of the best understood signalling pathways in eukaryotes. Comparison of this system with pathways in other fungal species has generated surprises and insights. Cloning and targetted disruption of genes encoding components of the pheromone response pathway has allowed the attribution of specific functions to these signal transduction components. In this review we describe current knowledge of the Kluyveromyces lactis mating system, and compare it with the well-understood S. cerevisiae pathway, emphasizing the similarities and differences in the heterotrimeric G protein activity. This mating pathway is controlled positively by both the Galpha and the Gbeta subunits of the heterotrimeric G protein.
酿酒酵母中的交配信息素应答途径是真核生物中理解最为透彻的信号通路之一。将该系统与其他真菌物种的信号通路进行比较，带来了惊喜与深刻见解。对编码信息素应答途径组分的基因进行克隆和定向破坏，使得能够明确这些信号转导组分的特定功能。在本综述中，我们描述了乳酸克鲁维酵母交配系统的现有知识，并将其与已充分了解的酿酒酵母信号通路进行比较，重点强调异源三聚体G蛋白活性方面的异同。该交配途径受到异源三聚体G蛋白的Gα和Gβ亚基的正向调控。
