Iavicoli Ivo, Falcone Gianluca, Alessandrelli Maria, Cresti Raffaella, De Santis Vincenzo, Salvatori Stefano, Alimonti Alessandro, Carelli Giovanni
Institute of Occupational Medicine, Catholic University of the Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy.
J Trace Elem Med Biol. 2006;20(1):25-31. doi: 10.1016/j.jtemb.2005.10.002. Epub 2005 Dec 13.
The aim of the study was to evaluate the serum and urine levels of cobalt (Co), chromium (Cr), manganese (Mn), molybdenum (Mo) and nickel (Ni) in patients who had undergone metal-on-metal hybrid surface arthroplasties on the supposition that a release of metals would occur due to the large head size of this type of implant. Metal levels were determined by using an analytical method based on sector field inductively coupled plasma mass spectrometry. Results showed a significant difference between patients and control subjects in mean levels of Co and Cr in serum (p<0.0001 and p=0.02, respectively) and in urine (p<0.0001 for both). No significant differences were observed in mean serum and urinary levels of Mn, Mo and Ni. Although the clinical consequences of these changes, if any, are unknown, further studies could be performed in a larger number of subjects implanted with a total surface arthroplasty at follow-up times over different periods.
本研究的目的是评估接受金属对金属混合表面置换术患者的血清和尿液中钴（Co）、铬（Cr）、锰（Mn）、钼（Mo）和镍（Ni）的水平，基于这样的假设：由于此类植入物的大头尺寸，会发生金属释放。金属水平通过基于扇形场电感耦合等离子体质谱的分析方法测定。结果显示，患者与对照受试者血清中Co和Cr的平均水平存在显著差异（分别为p<0.0001和p = 0.02），尿液中也存在显著差异（两者均为p<0.0001）。血清和尿液中Mn、Mo和Ni的平均水平未观察到显著差异。尽管这些变化（如果有）的临床后果尚不清楚，但可以在更多接受全表面置换术的受试者中，在不同时间段的随访中进行进一步研究。
